New combo treatment aims to smooth Crow's feet without surgery
NCT ID NCT07222176
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether using a peptide-based cream (P-TIOX) alongside a heat-based skin treatment (Tixel) reduces fine lines around the eyes better than the heat treatment alone. Twenty adults aged 30 and older with moderate to severe wrinkles will receive both treatments on one side of the face and only the heat treatment on the other. The study lasts about 9 weeks and uses photos and expert ratings to measure results.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- P-TIOX (a peptide-based cosmeceutical cream) and Tixel (a heat-based skin treatment device)
- What this could lead to
- If it works, this could point toward a more effective non-surgical option for reducing fine lines around the eyes.
- What could go wrong
- This is a very small, early-stage study with only 20 people. Results may not apply to everyone, and the improvement might be minor or not noticeable.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2025
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Severity of 2, 3, or 4 based on the 5-point severity scale of both periocular areas * 30 years of age or older * Willingness to comply with study visits * Willingness to discontinue use of other topical cosmeceuticals/retinoids to the periocular region for the duration of the study Exclusion Criteria: * Pregnant or breastfeeding * Prior treatment with periocular laser, energy-based devices, neuromodulators, or dermal fillers within the past six months * Prior surgical intervention in the periocular region within the past twelve months * Use of topical retinoids in the periocular area within the past four weeks * Known hypersensitivity to any component of P-TIOX * Presence of active dermatologic or ocular disease in the treatment area * Active systemic infection * Active cold sore/herpes labialis infection
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Main Line Center for Laser Surgery
Ardmore, Pennsylvania, 19107, United States