Triple threat: could adding radiation to chemo and immunotherapy improve breast cancer outcomes?
NCT ID NCT04443348
First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 31 times
Summary
This study tests whether adding different doses of radiation to a standard chemotherapy and immunotherapy (pembrolizumab) regimen before surgery can improve outcomes for people with lymph node-positive, HER2-negative breast cancer. About 120 participants will receive the combination, and researchers will measure immune cell activity in tumors and how many patients have no cancer left in their lymph nodes after treatment. The goal is to find a more effective pre-surgery treatment approach.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Dana Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Johns Hopkins
Baltimore, Maryland, 21231, United States
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MD Anderson Cancer Center
Houston, Texas, 77030, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02115, United States
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Mayo Clinic - Rochester
Rochester, Minnesota, 55905, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Montefiore Medical Center
The Bronx, New York, 10467, United States
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Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016, United States
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University of North Carolina Medical Center
Chapel Hill, North Carolina, 27514, United States
Conditions
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