Could adding radiation before surgery boost breast cancer treatment?

NCT ID NCT04443348

Ongoing Disease control Sponsor: Laura M. Spring, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study is for people with a certain type of breast cancer (HER2-negative) that has spread to lymph nodes. It tests giving a mix of chemotherapy, an immunotherapy drug (pembrolizumab), and different doses of radiation before surgery. The goal is to see if this approach helps the immune system fight the cancer better and improves outcomes. About 120 participants will be enrolled.

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Conditions

The condition(s) this trial relates to.

hormone receptor-positive breast cancer triple-negative breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIOPSY-PROVEN, POSITIVE LYMPH NODE(S) HORMONE RECEPTOR POSITIVE (HR+), HER2-NEGATIVE BREAST CANCER TRIPLE NEGATIVE BREAST CANCER

Contacts and locations

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Locations

Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Johns Hopkins

Baltimore, Maryland, 21231, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Massachusetts General Hospital

Boston, Massachusetts, 02115, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Sibley Memorial Hospital

Washington D.C., District of Columbia, 20016, United States
University of North Carolina Medical Center

Chapel Hill, North Carolina, 27514, United States

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