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Ozone or shock waves: which works better for stubborn achilles pain?

NCT ID NCT07412652

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested three treatments for long-term Achilles tendon pain: ozone injections, shock wave therapy, and standard exercise. 63 adults with persistent symptoms took part. The goal was to see which approach best reduces pain and improves daily function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozone injection
What this could lead to
If successful, this could provide a new, non-surgical option for easing chronic Achilles tendon pain and improving function.
What could go wrong
This is a small, completed trial with 63 participants, so results may not apply to everyone. Ozone therapy is not widely used and may have unknown long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

63 people

The number who actually took part.

Started

May 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients aged 18 to 65 years. Patients with a diagnosis of Achilles tendinopathy confirmed by ultrasonography or magnetic resonance imaging (MRI). Patients with persistent symptoms despite completion of conservative treatment. Volunteers who agree to participate in the study. Exclusion Criteria: Patients with symptoms lasting less than 12 weeks. Presence of contraindications to extracorporeal shock wave therapy (ESWT), including pregnancy; history of thrombosis; use of anticoagulant medications; coagulation disorders such as hemophilia; systemic conditions; or localized conditions at the treatment site such as active infection or malignant tumors. Presence of contraindications to local ozone injection, including pregnancy; glucose-6-phosphate dehydrogenase (G6PD) deficiency; favism; uncontrolled hyperthyroidism; thrombocytopenia; severe cardiovascular conditions; and use of angiotensin-converting enzyme (ACE) inhibitors. History of neurological disease, muscle disease, or peripheral vascular disease. Presence of congenital or acquired deformities of the knee and/or ankle. Receipt of physical therapy modalities applied to the Achilles tendon within the last 6 weeks. Receipt of any therapeutic injection to the Achilles tendon within the last 12 weeks. History of direct trauma to the symptomatic Achilles tendon or Achilles tendon rupture. History of surgical treatment involving the Achilles tendon or ankle for any reason. History of foot or ankle dislocation or fracture within the past 1 year. Presence of systemic inflammatory diseases that may affect tendon structure, such as ankylosing spondylitis, reactive arthritis, or psoriatic arthritis. Patients with isolated insertional Achilles tendinopathy without tenderness in the mid-portion of the tendon \-

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Ankara Bilkent City Hospital - Physical Medicine and Rehabilitation Hospital

    Ankara, Cankaya, 06800, Turkey (Türkiye)

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