Ozone or shock waves: which works better for stubborn achilles pain?
NCT ID NCT07412652
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested three treatments for long-term Achilles tendon pain: ozone injections, shock wave therapy, and standard exercise. 63 adults with persistent symptoms took part. The goal was to see which approach best reduces pain and improves daily function.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ozone injection
- What this could lead to
- If successful, this could provide a new, non-surgical option for easing chronic Achilles tendon pain and improving function.
- What could go wrong
- This is a small, completed trial with 63 participants, so results may not apply to everyone. Ozone therapy is not widely used and may have unknown long-term effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
63 people
The number who actually took part.
- Started
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May 2025
- Finished
-
Jan 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patients aged 18 to 65 years. Patients with a diagnosis of Achilles tendinopathy confirmed by ultrasonography or magnetic resonance imaging (MRI). Patients with persistent symptoms despite completion of conservative treatment. Volunteers who agree to participate in the study. Exclusion Criteria: Patients with symptoms lasting less than 12 weeks. Presence of contraindications to extracorporeal shock wave therapy (ESWT), including pregnancy; history of thrombosis; use of anticoagulant medications; coagulation disorders such as hemophilia; systemic conditions; or localized conditions at the treatment site such as active infection or malignant tumors. Presence of contraindications to local ozone injection, including pregnancy; glucose-6-phosphate dehydrogenase (G6PD) deficiency; favism; uncontrolled hyperthyroidism; thrombocytopenia; severe cardiovascular conditions; and use of angiotensin-converting enzyme (ACE) inhibitors. History of neurological disease, muscle disease, or peripheral vascular disease. Presence of congenital or acquired deformities of the knee and/or ankle. Receipt of physical therapy modalities applied to the Achilles tendon within the last 6 weeks. Receipt of any therapeutic injection to the Achilles tendon within the last 12 weeks. History of direct trauma to the symptomatic Achilles tendon or Achilles tendon rupture. History of surgical treatment involving the Achilles tendon or ankle for any reason. History of foot or ankle dislocation or fracture within the past 1 year. Presence of systemic inflammatory diseases that may affect tendon structure, such as ankylosing spondylitis, reactive arthritis, or psoriatic arthritis. Patients with isolated insertional Achilles tendinopathy without tenderness in the mid-portion of the tendon \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ankara Bilkent City Hospital - Physical Medicine and Rehabilitation Hospital
Ankara, Cankaya, 06800, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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