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Ozone treatment tested to boost heart function in failure patients

NCT ID NCT07134972

Disease control Sponsor: Ekrem Bilal Karaayvaz Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed trial tested whether ozone therapy can help people with heart failure and reduced ejection fraction. Sixty participants received ozone infusions twice a week for two months. Researchers measured coronary flow reserve, exercise capacity, and heart function before and after treatment. The goal was to see if ozone could improve blood flow and reduce heart failure episodes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozone therapy (ozonized blood infusion)
What this could lead to
If it works, this could point toward a complementary therapy to improve blood flow and exercise ability in heart failure patients.
What could go wrong
This is a small, completed trial with only 60 participants, so results may not apply widely. Ozone therapy is experimental and not a standard heart failure treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Jan 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Previosuly known coronary angiography with less than % 50 stenosis * Echocardiography with ejection fraction of less than % 40 * Patients with previosly planned for ozone treatment for non-chronic disease or conditions Exclusion Criteria: * Known chronic diseases or conditions that effect endothelial functions. * Previosly had acute coronary syndrome or stent implantation or any coronary intervention. * Smokers

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Conditions

The condition(s) this trial relates to.

heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure and reduced ejection fraction

Contacts and locations

Locations

  • Medicana International Hospital Istanbul

    Istanbul, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.