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Ozone therapy may help gums heal faster after surgery

NCT ID NCT06753305

Symptom relief Sponsor: Kutahya Health Sciences University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether applying ozone therapy (active oxygen) to the gums after gum surgery can help them heal better and reduce pain. 48 adults with gum overgrowth will be randomly assigned to get either standard gum paste or gum paste plus ozone therapy. The researchers will check healing, inflammation, and quality of life one month after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozone therapy (active oxygen)
What this could lead to
If it works, this could point toward a simple way to improve gum healing and reduce pain after gum surgery.
What could go wrong
This is a small, early-stage trial with only 48 people. The results may not apply to everyone, and the benefits might be small or not show up at all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2022

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. be over 18 years old 2. Systemically healthy individuals 3. Gingival enlargement due to inflammation in at least 4 teeth in the maxillary anterior region 4. Horizontal and vertical gingival growth index score of 1 or 2 5. Gingival thickness more than 2 mm 6. Good oral hygiene 7. No loss of clinical attachment Exclusion Criteria: 1. Pregnancy 2. Hereditary gingival fibromatosis 3. Drug-induced gingival enlargement 4. Allergy 5. Presence of systemic conditions requiring antibiotic prophylaxis 6. Acute and untreated periodontitis

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Conditions

The condition(s) this trial relates to.

Gingival Hyperplasia gingival overgrowth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival enlargement

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kütahya Health Sciences University Faculty of Dentistry

    RECRUITING

    Kütahya, 43100, Turkey (Türkiye)

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