Ozonated gel or platelet fibrin: which heals gum wounds better?
NCT ID NCT07320391
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested two treatments—ozonated gel and titanium platelet-rich fibrin (T-PRF)—on 39 people to see which helps palatal wounds heal better after gum graft surgery. Participants were followed for 14 days to measure pain and wound size. The goal is to find a simple way to reduce discomfort and speed recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ozonated gel and titanium platelet-rich fibrin (T-PRF)
- What this could lead to
- If it works, this could point toward a better way to reduce pain and speed healing after gum graft surgery.
- What could go wrong
- This is a small, completed trial with only 39 participants, so results may not apply to everyone. The treatments are not widely used, and benefits may be modest.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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39 people
The number who actually took part.
- Started
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May 2024
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Isolated gingival recession defects on the mandibular and maxillary anterior teeth with insufficient keratinized gingiva. * Good oral hygiene Exclusion Criteria: * Patients reporting systemic conditions that may compromise healing or bone metabolism * Patients having a history of radiotherapy, chemotherapy or bisphosphonate therapy. * Pregnant women or those planning to get pregnant during the study course * History of periodontal disease or previous periodontal surgery on the experimental sites * Smoking or any other deleterious habits.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Outpatient Clinic of Periodontology and Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gum graft surgery: does the bed matter for thin gums?
- Boosting gum grafts: do blood or gel Add-Ons reduce shrinkage?
- Can a new flap technique better cover receding gums?
- A new twist on gum surgery could better cover exposed roots
- Gum graft boost: growth factors may strengthen receding gum repair
- Micro-needling vs. gum graft: a tiny trial tests a simpler fix for receding gums