Could too much oxygen harm sepsis patients? new study investigates
NCT ID NCT07332637
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will follow 110 adults with sepsis in the ICU to see if the amount of oxygen they receive in the first 24 hours is linked to changes in a blood marker called the uric acid/albumin ratio (UAR). The UAR may indicate oxidative stress and inflammation. Researchers will not change any treatments—they will simply observe standard care and measure UAR at admission and 24 hours later. The goal is to learn whether high oxygen exposure might cause extra stress on the body and whether UAR could be a useful early warning sign.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could show that a simple blood test (uric acid/albumin ratio) can help doctors monitor oxygen-related stress in sepsis patients, potentially guiding safer oxygen use.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly change care. It only looks at a small group of 110 patients, and results may not apply to all sepsis patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 110 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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May 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of adult patients aged 18 years and older who are admitted to a tertiary-level intensive care unit with a diagnosis of sepsis or septic shock according to Sepsis-3 criteria. All included patients receive oxygen therapy as part of standard clinical care, with a fraction of inspired oxygen (FiO₂) of at least 0.3 during the early phase of ICU admission. The population represents critically ill patients requiring close monitoring, respiratory support, and comprehensive laboratory evaluation. Patients with conditions or treatments that may independently affect uric acid or albumin metabolism are excluded to allow a clearer assessment of the relationship between oxygen exposure and changes in the uric acid/albumin ratio.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients aged 18 years or older * Admission to the intensive care unit with a diagnosis of sepsis according to Sepsis-3 criteria * Receipt of oxygen therapy with FiO₂ ≥ 0.3 during ICU stay * Availability of serum uric acid, albumin, and lactate measurements and calculated SOFA scores at ICU admission * Availability of serum uric acid and albumin levels both at ICU admission (baseline) and at 24 hours * Provision of informed consent by the patient or a legally authorized representative Exclusion Criteria: * Age younger than 18 years * Pregnant or breastfeeding women * Chronic kidney disease or receipt of renal replacement therapy * Advanced liver failure (Child-Pugh class C) * Receipt of albumin infusion within the previous 24 hours * Use of medications that affect uric acid metabolism (e.g., allopurinol, febuxostat, rasburicase) * History of active gout attack or malignancy-related hyperuricemia * Missing serum uric acid or albumin measurements at baseline or 24 hours * Inability to obtain informed consent from the patient or a legally authorized representative
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a computer model speed up sepsis blood tests?
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- Can the immune system reveal who will suffer kidney injury after sepsis?
- A routine calcium reading could reveal how sick a sepsis patient really is