Can extra oxygen ease High-Altitude heart strain?
NCT ID NCT06489756
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether giving extra oxygen can lower blood pressure in the lungs of people who live above 2500 meters and have high altitude pulmonary hypertension. Researchers measured heart changes with ultrasound in 48 highlanders while they breathed either oxygen or regular air. The goal was to see if oxygen therapy could help manage this condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- supplemental oxygen therapy
- What this could lead to
- If successful, this could point toward a simple oxygen-based treatment to manage high altitude pulmonary hypertension in people living at high altitudes.
- What could go wrong
- This is a small, completed study with only 48 participants. The results may not apply to all highlanders, and oxygen therapy is a temporary measure, not a cure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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48 people
The number who actually took part.
- Started
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Jul 2024
- Finished
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Dec 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Permanently living \>2500 m * HAPH diagnosed with a minimum RV/RA of 30 mmHg assessed by echocardiography at an altitude of 3200 m * Written informed consent Exclusion Criteria: * Highlanders who cannot follow the study investigations, * Patients with moderate to severe concomitant lung disease (FEV1\<70% or forced vital capacity \<70%), severe parenchymal lung disease, heavy smoking \>20 cigarettes/day or \>20 pack-years. * Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months * Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Aksay Medical Center
Aksay Plateau, Naryn, Kyrgyzstan, Kyrgyzstan
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