Mountain brain fog: can oxygen fix it?
NCT ID NCT07651917
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether breathing extra oxygen can improve thinking and reaction time in healthy people who live at high altitude (about 2500 meters). Fifty Kyrgyz adults will receive both real oxygen and a sham treatment to compare. The goal is to see if mental changes caused by low oxygen are reversible.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- supplemental oxygen therapy
- What this could lead to
- If it works, this could show that extra oxygen can reverse altitude-related mental sluggishness in healthy highlanders.
- What could go wrong
- This is a small, early-phase study in a specific group (Kyrgyz highlanders). Results may not apply to others, and the effect may be small or absent.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Jul 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Signed written consent * Age \>18 * Kyrgyz ethnicity * Born, raised and living at approximately 2500 m * Native or fluent in Russian language Exclusion Criteria: * Severe disease such as unstable hypertension, coronary heart disease, pulmonary diseases, others. * Regular use of medication that interfere with sleep or breathing such as benzodiazepines, opioids, acetazolamide * Heavy smoking of \>20 cigarettes per day * Not able to read or adhere to the study protocol
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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