Oxygen dosing during surgery: a key to better lung recovery?
NCT ID NCT06746181
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 95 adults having abdominal surgery to see if different oxygen levels during the procedure affect how well the lungs work afterward. Doctors measured lung stiffness and checked for complications like collapsed lungs or low oxygen. The goal is to find the best oxygen setting to keep lungs healthy during surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- different inspired oxygen concentrations (FiO2)
- What this could lead to
- If successful, this could help doctors choose the best oxygen level during surgery to improve lung function and reduce complications like collapsed lungs.
- What could go wrong
- This is a small, single-center study with only 95 participants. Results may not apply to all patients or surgeries, and the benefit may be small.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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95 people
The number who actually took part.
- Started
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Apr 2025
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 64 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ASA physical status classification: I or II. * Adults aged 18 to 64 years, regardless of gender. * BMI between 18 kg/m² and 25 kg/m². * Patients undergoing elective abdominal surgery under general anesthesia. * Patients with estimated operating time ≥1.5h and intraoperative bleeding ≤500ml. * Patients who have provided written informed consent after understanding the study purpose, procedures, and potential risks. Exclusion Criteria: * Previous thoracic surgery. * Chest X-ray or CT suggestive of pneumothorax or alveoli. * Lung disease: chronic bronchitis, asthma, moderate to severe obstructive ventilatory dysfunction. * Preoperative pulse oxygen saturation (SpO2) \<90% on breathing air or SpO2 \<95% on oxygen. * Contraindications to lung reanimation: high intracranial pressure, hypovolemic shock, right heart failure. * Severe heart disease (New York Heart Association, NYHA class III or IV. * Acute coronary syndrome or sustained ventricular tachyarrhythmia). * Participation in other interventional studies or refusal of enrollment.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Northern Jiangsu People's Hospital
Yangzhou, Jiangsu, 225001, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.