Could extra oxygen during surgery prevent wound infections?
NCT ID NCT06108791
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This study compares giving 80% oxygen versus 33% oxygen during liver or gallbladder surgery to see if higher oxygen levels reduce surgical site infections. About 146 adults having planned abdominal surgery lasting over two hours will take part. Researchers will track infections for 30 days after surgery and also watch for any lung problems.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- oxygen (80% vs 33% inspired fraction)
- What this could lead to
- If higher oxygen works, it could offer a simple, low-cost way to lower infection risk after abdominal surgery.
- What could go wrong
- This is a small, early-stage study. Higher oxygen may not reduce infections and could increase lung complications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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146 people
The number who actually took part.
- Started
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Apr 2025
- Finished
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Jun 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * \- BMI of \<35 kg/m2 * scheduled for elective abdominal laparotomy/ laparoscopy under general anesthesia with an expected surgical time longer than 2 h. * ASA I and II Exclusion Criteria: * \- Patients undergoing minor procedures, where the expected duration of surgery will be less than 1 hour. * emergency surgeries for bowel obstruction. * abdominal surgery for vascular or plastic indications. * patients with a recent history of fever, * patients with uncontrolled diabetes mellitus, * patient with known immunological dysfunction (on steroids, decompensated liver disease, HIV, etc.).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Assiut University
Asyut, 71515, Egypt
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