Bladder drug may speed up recovery after prostate surgery
NCT ID NCT06966778
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether oxybutynin, a medication used for overactive bladder, can help men recover urinary control sooner after robotic prostate removal for prostate cancer. About 135 participants will take either the drug or a placebo daily for up to 3 months. Researchers will track how many men achieve continence (using 0-1 pads per day) within 12 months after surgery.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 135 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis: Patients with localized prostate cancer who are scheduled to undergo robot-assisted radical prostatectomy (RARP). * Age: Participants must be 18 years or older, with no upper age limit. * Consent: Participants must provide written informed consent before undergoing any study procedures. * Ability to Follow Protocol: Participants must be able to follow the protocol procedures throughout the study. Exclusion Criteria: * Surgical Complications: Participants who experience surgical complications during or after RARP requiring extraordinary medical or surgical treatment. * Other Urinary Conditions: Participants with other diseases causing lower urinary tract symptoms (LUTS) or bladder pain, including: * \- Benign prostatic hyperplasia (BPH), chronic prostatitis, interstitial cystitis, painful bladder syndrome, or urinary tract infection. * \- Overactive bladder or any other condition affecting bladder function. * Chronic Medication: Participants with long-term use of medications such as: * \- Alpha-blockers, antimuscarinics, or anticholinergics. * Glaucoma: Participants with narrow-angle glaucoma. * Urinary Retention: Participants with a history of urinary retention. * Gastrointestinal Motility Issues: Participants with severe conditions affecting gastrointestinal motility. * Concurrent Medications: Participants who are taking medications that are prohibited by the study protocol (e.g., cholinergic drugs, azole antifungals, smooth muscle relaxants).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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National Taiwan University Hospital
RECRUITINGTaipei, 100, Taiwan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Light-Based imaging aims to spot prostate cancer left behind after surgery
- Light plus drug: a new way to zap prostate cancer without surgery?
- Can a targeted radiation boost improve prostate cancer control?
- Can sound waves offer a lasting fix for prostate problems?
- A sharper eye on prostate cancer: could new imaging spare healthy tissue?
- Could a smartwatch and remote coaching cut incontinence after prostate surgery?