Could a single dose beat brain worms? new trial aims to find out

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female individuals between 18 and 75 years of age, with suspected viable or degenerating intraparenchymal brain cysticercosis on neuroimaging (CT or MRI) and fulfill the diagnostic criteria for solitary cysticercus granuloma (Rajshekhar and Chandy, 1997) 2. If female of child-bearing potential and men, willing to use an adequate method of contraception\*, including implants, injectables, combined oral contraceptives, effective intrauterine devices, sexual abstinence, or vasectomized partner while participating in the study. 3. Patients with normal laboratory values for hemoglobin, platelet counts, total white blood cells, glucose, creatinine, bilirubin, ALT, and AST. 4. Availability to grant informed consent. Exclusion Criteria: 1. Multiple lesion sites or more than two adjacent lesions. 2. Suspected neurotuberculosis (Rajshekhar's criteria) \[66,67\] 3. More than two viable brain cysts. 4. Large brain cysts (\> 3cm in diameter) 5. Subarachnoid neurocysticercosis or intraventricular 6. Untreated ocular cysticercosis 7. Previous therapy with ABZ (does not include patients who received single-dose 400 mg ABZ for intestinal parasites), or PZQ in the past twelve months. 8. Active pulmonary tuberculosis evidenced by a positive chest X-ray and positive sputum smears. 9. Systemic disease other than NCC that may affect therapy or short-term prognosis, including but not limited to chronic renal failure, hepatic insufficiency, cardiac failure, and steroid-dependent immune diseases. 10. Patients in unstable condition or with severe intracranial hypertension (ICH). Definition of severe ICH for this study would be the presence of headaches, nausea, and vomiting, and papilledema at fundoscopic examination. 11. Pregnancy 12. History of hypersensitivity to ABZ or PZQ 13. Concurrent treatment with cimetidine, ranitidine, or theophylline. 14. Chronic alcohol or drug abuse. 15. Positive to Strongyloides infection 16. History of reported allergy to contrast substances used in MRI.