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Low-Dose pill vs. Progestin-Only: which stops ovulation best?

NCT ID NCT03106454

Knowledge-focused Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a very low-dose combination birth control pill (10 mcg estrogen) prevents ovulation better than a progestin-only pill with a similar amount of progestin. Fifty-eight women took one of the two pills for a few months. Researchers checked ovulation using blood tests and also looked at cervical mucus quality. The goal was to see which pill works better and has fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ethinyl estradiol and norethindrone acetate combination pill (Loestrin) vs. norethindrone-only pill (Micronor)
What this could lead to
If successful, this could help doctors choose the best birth control pill for each woman, balancing effectiveness and side effects.
What could go wrong
This is a small, completed study with only 58 participants, so results may not apply to all women. It does not test long-term safety or real-world use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

58 people

The number who actually took part.

Started

Aug 2014

Finished

Jan 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Reproductive aged women 18-45 years old. * Menstrual cycle length 25-35days * BMI less than or equal to 40 * English or Spanish speaking Exclusion Criteria: * Pregnant or breastfeeding in the previous 3 months. * Use of OC, hormonal vaginal rings or patches, levonorgestrel containing intrauterine device, or etonogestrel implant in the previous 1 month. No use of depot medroxyprogesterone acetate (DMPA) injection in the previous 6 months and at least one menses since discontinuation. * Medical contraindications to estrogen or progestin use. Specifically: smoking among participants over 35 years old, migraines with aura, history of blood clots, ischemic heart disease, stroke, breast cancer, cervical cancer, liver disease, symptomatic gallbladder disease, uncontrolled hypertension, antiphospholipid antibody syndrome, hyperlipidemia, diabetes with end organ damage (retinopathy, nephropathy, neuropathy) or diagnosis \>20 years ago, organ transplant * Desire to become pregnant in the next 4 months

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contraception Ovulation

Contacts and locations

Locations

  • Brian T. Nguyen

    Los Angeles, California, 90065, United States

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