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New study tracks ovarian health after chemo in young women

NCT ID NCT02467231

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 196 women aged 11-35 who are receiving chemotherapy for cancer. Researchers measure hormone levels and ovarian follicles before, during, and after treatment to see how the ovaries are affected. The goal is to better understand the risk of early menopause and fertility problems after cancer therapy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better predict and manage fertility risks for young women undergoing chemotherapy.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly improve outcomes. Results may take years to influence clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

196 people

The number who actually took part.

Start date

Feb 2009

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Postmenarchal females, ages 11-35, who will require chemotherapy; An unexposed cohort balanced to the exposed cohort with respect to age and oral contraceptive use.

Ages

11 to 35 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for exposed population: * Postmenarchal females to be treated with chemotherapy * between the ages of 11-35 years, * with a uterus and at least one ovary Inclusion Criteria for unexposed population: * healthy postmenarchal females * no prior or planned exposure to chemotherapy * between the ages of 11-35, * with a uterus and at least one ovary * regular menstrual cycles (21-35 days) Exclusion criteria for all subjects: * positive pregnancy test at enrollment * lactation within the previous 1 month, * previous treatment with chemotherapy or radiation therapy with the exception of radioactive iodine for thyroid cancer. * previous diagnosis of an illness associated with premature ovarian failure (Turner's syndrome, Fragile X permutation carrier) * endocrine disorder associated with irregular menstrual cycles (Cushing's disease, Thyroid disease, hyper-prolactinemia, congenital adrenal hyperplasia). Additional exclusions for the unexposed population: * a history of infertility, defined as at least 12 months of unprotected intercourse without conception * polycystic ovary syndrome (PCOS)

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Conditions

The condition(s) this trial relates to.

cancer premature menopause primary ovarian failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Effects of chemotherapy Premature ovarian failure

Contacts and locations

Locations

  • University of Pennsylvania, Reproductive Research Unit

    Philadelphia, Pennsylvania, 19104-5509, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.