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Heart stent showdown: which technique wins for left main blockages?

NCT ID NCT07596706

Disease control Sponsor: Istanbul Mehmet Akif Ersoy Educational and Training Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study compares two ways to place stents in the left main coronary artery when there is a blockage at the opening of a branch. One method places a stent only in the blocked branch, while the other extends a stent from the main artery into the branch. Researchers will track 1000 patients to see which approach leads to fewer heart attacks, deaths, or repeat procedures. The goal is to find the safer and more effective technique for these high-risk blockages.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
drug-eluting stent
What this could lead to
If this trial succeeds, it could clarify which stenting technique is safer for treating blockages at the left main coronary artery, potentially reducing heart attacks and the need for repeat procedures.
What could go wrong
This is an observational study, not a randomized trial, so results may be influenced by factors other than the stenting technique. The findings may not apply to all patients with coronary artery disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Medina 0.0.1 and 0.1.0 left main bifurcation disease

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ostial left anterior descending artery or left circumflex artery disease * Coronary intervention with second or third generation drug-eluting stent Exclusion Criteria: * Severe left main disease (≥30%, intravascular ultrasound plaque burden \>50%) * History of coronary bypass grafting * Cardiogenic shock * Left main diameter greater than stent expansion capacity (for crossover group) * In-stent restenosis * End-stage liver or kidney disease (cirrhosis, hemodialysis-dependent chronic kidney disease), * Coronary intervention with bare-metal stent * Early discontinuation or inappropriate use of DAPT treatment * Patients lost to follow-up * Patient life expectancy \<1 year (such as cancer)

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Conditions

The condition(s) this trial relates to.

coronary artery disorder coronary stenosis stenosis or atrophy of the coronary ostium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery disease (CAD) Coronary bifurcation lesion Left main coronary artery stenosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Hospital

    ACTIVE_NOT_RECRUITING

    Istanbul, Please Select, 33484, Turkey (Türkiye)

  • İstanbul Mehmet Akif Ersoy Thoracic And Cardiovascular Surgery Training and Research Hospital

    RECRUITING

    Istanbul, 33484, Turkey (Türkiye)

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