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Why do some osteoporosis drugs cause rare thigh breaks? scientists hunt for answers.

NCT ID NCT04110795

Knowledge-focused Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares 330 people who had a rare thigh bone fracture while on osteoporosis medication with 660 similar patients who did not. Researchers are looking for genetic differences and other clinical factors that might explain why some people get these fractures. The goal is to better predict risk and personalize osteoporosis care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors identify who is at higher risk for atypical femur fractures before prescribing osteoporosis medications.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear genetic links, and results may not change clinical practice for years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2018

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Community based population in Ontario and British Columbia Canada

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Cases: Have experienced a confirmed, documented Atypical femur fracture * Controls: currently on anti-resorptive therapy, matches AFF case by age, race and length of ART use Exclusion Criteria: \-

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atypical femur fracture

Contacts and locations

Locations

  • Adachi Medical Centre

    Hamilton, Ontario, L8N 1Y2, Canada

  • Bone Research & Education Centre

    Oakville, Ontario, L6M 1M1, Canada

  • University Health Network, TGH

    Toronto, Ontario, M5G 2C4, Canada

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