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Hands-On therapy may clear Pain-Fueled brain fog

NCT ID NCT04058431

Symptom relief Sponsor: Midwestern University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether osteopathic manipulation, a type of hands-on treatment, can help adults aged 40 and older who have both pain and thinking problems like trouble with memory or focus. The researchers will measure changes in pain, thinking skills, and stress-related markers in the blood. The goal is to see if this treatment can ease both the physical and mental effects of pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2017

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 40 years of age or older; 2. seeking treatment for acute or chronic pain (neck, thoracic, shoulder, back) 3. gives a positive response to the item, "Have you had thinking problems because of your pain?"; 4. agree to forego extra-trial manipulation (e.g., massage, chiropractic, physical therapy); 5. Score \> 23 on the Telephone Interview for Cognitive Status; 6. written informed consent. Exclusion Criteria: 1. recent (\< 2 month) or planned surgery within the duration of the study; 2. use of medication that could interfere with cytokine measurements; 3. recent (\< 2 month) changes to psychotropic medication within the duration of the study; 4. history of manipulation within the past six months. 5. diagnosed neurocognitive disorders; 6. contraindication to receiving OMT.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Musculoskeletal Pain Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive change Musculoskeletal pain

Contacts and locations

Locations

  • Midwestern Multispecialty Clinic

    Downers Grove, Illinois, 60515, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.