Real-World study tracks osimertinib combo for lung cancer

NCT ID NCT06538038

Knowledge-focused Sponsor: PrECOG, LLC. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 2 times

Summary

This study is watching how patients with EGFR-mutated non-small cell lung cancer do when they receive standard treatment with osimertinib (Tagrisso) alone or with chemotherapy in routine medical practice. About 538 people with advanced lung cancer will be followed to see how long they live without the cancer getting worse and overall survival. The goal is to gather real-world data on safety and effectiveness outside of a clinical trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: osimertinib (Tagrisso) with or without chemotherapy (cisplatin, carboplatin, pemetrexed)
What this could lead to: If successful, this study could help doctors understand which patients benefit most from adding chemotherapy to osimertinib in routine practice.
What could go wrong: This is an observational study, not a controlled trial, so results may be influenced by patient selection and real-world variability. It won't prove cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

200 people

The number who actually took part.

Started

Sep 2024

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with EGFR-mutated NSCLC, not being treated in a clinical trial but receiving osimertinib +/- chemotherapy at academic and community practices participating in PrE1702 registry.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient must have a pathologically-confirmed diagnosis of non-small cell lung cancer (NSCLC). * Patient must have advanced disease, defined as IIIB (not amenable to definitive multi-modality therapy), IIIC, or IV (includes local or distant recurrent disease after a prior diagnosis of Stage I-III disease). All staging is via the American Joint Committee on Cancer (AJCC)/International Association for the Study of Lung Cancer (IASLC) 8th edition staging criteria. * Patient tumor must have somatic activating sensitizing mutation in EGFR (e.g., but not limited to Exon 19 deletion, L858R, E709X, G719X, exon 19 insertions, L861Q, S768I). Patients with non-sensitizing mutations in EGFR (EGFR exon 20 insertions) are not eligible. Plasma, cytology, or tumor tissue can be utilized for standard of care mutation testing. * Prior chemotherapy and/or immunotherapy administered as primary treatment for NSCLC before EGFR mutation was identified is allowed ≤ 45 days of study registration to allow for return of sequencing information. * Prior treatment with osimertinib administered as primary treatment for NSCLC is allowed ≤ 30 days of study registration (prior treatment with any other EGFR TKI agent is not allowed). * Patient must not be participating in EA5182 or any other cancer treatment trial. Osimertinib or osimertinib + chemotherapy/immunotherapy given as first-line treatment for this disease cannot be given as part of a clinical trial. * Patients that have received prior radiation therapy in any setting for this disease are eligible. * Adults age ≥ 18 years.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Epidermal growth factor receptor gene mutation are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Epidermal growth factor receptor gene mutation Non-small cell lung cancer Stage III lung cancer Stage IV lung cancer

Contacts and locations

Locations

AHC Germantown Health Center

Germantown, Wisconsin, 53022, United States
Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Advocate Christ Medical Center

Oak Lawn, Illinois, 60453, United States
Advocate Good Shepherd Hospital

Barrington, Illinois, 60010, United States
Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657, United States
Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068, United States
Advocate South Suburban Hospital

Hazel Crest, Illinois, 60429, United States
Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States
Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090, United States
Atlantic Health Cancer Consortium Community Oncology Research Program

Morristown, New Jersey, 07960, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005, United States
Aultman

Canton, Ohio, 44710, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States
Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209, United States
Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Racine

Racine, Wisconsin, 53406, United States
Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Aurora NCORP

Milwaukee, Wisconsin, 53215, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Aurora Saint Luke's South Shore

Cudahy, Wisconsin, 53110, United States
Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233, United States
Aurora West Allis Medical Center

Milwaukee, Wisconsin, 53227, United States
Baptist Cancer Center - Grenada

Grenada, Mississippi, 38901, United States
Baptist Memorial Hospital and Cancer Center - Collierville

Collierville, Tennessee, 38017, United States
Baptist Memorial Hospital and Cancer Center - Desoto

Southhaven, Mississippi, 38671, United States
Baptist Memorial Hospital and Cancer Center - Golden Triangle

Columbus, Mississippi, 39705, United States
Baptist Memorial Hospital and Cancer Center - Memphis

Memphis, Tennessee, 38120, United States
Baptist Memorial Hospital and Cancer Center - Oxford

Oxford, Mississippi, 38655, United States
Baptist Memorial Hospital and Cancer Center - Union

New Albany, Mississippi, 38652, United States
Baptist Memorial Hospital for Women

Memphis, Tennessee, 38120, United States
Bayhealth

Dover, Delaware, 19901, United States
Cambridge Medical Center

Cambridge, Minnesota, 55008, United States
Carle Cancer Institute Normal

Normal, Illinois, 61761, United States
Carle Founation Hospital

Urbana, Illinois, 61801, United States
Community Medical Center

Scranton, Pennsylvania, 18510, United States
Einstein Medical Center

Philadelphia, Pennsylvania, 19141, United States
Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, North Carolina, 28374, United States
Fowler Family Cancer Center - Jonesboro

Jonesboro, Arkansas, 72401, United States
Geisinger Cancer Services-Pottsville

Pottsville, Pennsylvania, 17901, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Center-Cancer Center Hazleton

Hazleton, Pennsylvania, 18201, United States
Geisinger Medical Group

State College, Pennsylvania, 16801, United States
Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Good Samaritan University Hospital

West Islip, New York, 11795, United States
Greater Baltimore Medical Center

Baltimore, Maryland, 21204, United States
Gundersen Lutheran Medical Foundation

La Crosse, Wisconsin, 54601, United States
Health Partners Inc.

Minneapolis, Minnesota, 55454, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
JPS Oncology & Infusion Center

Fort Worth, Texas, 76104, United States
Jackson Oncology Associates PLLC

Jackson, Mississippi, 39202, United States
Jefferson Torresdale Hospital

Philadelphia, Pennsylvania, 19114, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States
John Muir Health

Walnut Creek, California, 94598, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Lankenau Medical Center

Paoli, Pennsylvania, 19301, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Liberty County Cancer Care

Hinesville, Georgia, 31313, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Regional Cancer Care

Jesup, Georgia, 31545, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: SJC Bluffton Campus

Bluffton, South Carolina, 29910, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: South Carolina Cancer Specialists

Hilton Head Island, South Carolina, 29926, United States
Lewistown Hospital

Lewistown, Pennsylvania, 17044, United States
Lowell General Hosptial

Lowell, Massachusetts, 01854, United States
Marshfield Medical Center

Marshfield, Wisconsin, 54449, United States
Mercy Clinic Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Clinic East Communities

St Louis, Missouri, 63128, United States
Mercy Clinic East Communities

St Louis, Missouri, 63141, United States
Mercy Clinic Fort Smith Communities

Fort Smith, Arkansas, 72903, United States
Mercy Clinic Joplin, LLC

Joplin, Missouri, 64804, United States
Mercy Clinic Oklahoma Communities, Inc.

Oklahoma City, Oklahoma, 73120, United States
Mercy Clinic Springfield Communities

Springfield, Missouri, 65804, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Research

Fort Smith, Arkansas, 72903, United States
Mercyhealth Hospital and Cancer Center - Janesville

Janesville, Wisconsin, 53548, United States
Metro MN

Saint Louis Park, Minnesota, 55426, United States
Miami Valley Cancer Care and Infusion

Greenville, Ohio, 45331, United States
Miami Valley Hospital North

Englewood, Ohio, 45415, United States
Miami Valley Hospital South

Centerville, Ohio, 45459, United States
Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Mississippi Baptist Medical Center

Jackson, Mississippi, 39202, United States
Montefiore

New York, New York, 10467, United States
Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
Morristown Medical Center

Morristown, New Jersey, 07960, United States
New Ulm Medical Center

New Ulm, Minnesota, 56073, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States
Northwestern Medicine Glenview Outpatient Center

Glenview, Illinois, 60026, United States
Northwestern Medicine Grayslake Outpatient Center

Grayslake, Illinois, 60030, United States
Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045, United States
Northwestern Medicine Orland Park

Orland Park, Illinois, 60462, United States
Northwestern University

Chicago, Illinois, 60611, United States
Overlook Medical Center

Summit, New Jersey, 07901, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
ProHealth

Waukesha, Wisconsin, 53022, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
SUNY Upstate Medical University

Syracuse, New York, 13210, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Satellite of Bayhealth Sussex

Milford, Delaware, 19901, United States
Sibley Johns Hopkins University

Washington D.C., District of Columbia, 20016, United States
Sidney Kimmel Cancer Center Washington Township

Sewell, New Jersey, 08080, United States
Stanford Cancer Center Emeryville

Emeryville, California, 94608, United States
Stanford Cancer Center South Bay

San Jose, California, 95124, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
The Cancer Institute at St. Francis Hospital

East Hills, New York, 11548, United States
The Valley Hospital - Luckow Pavilion

Paramus, New Jersey, 07652, United States
ThedaCare Cancer Care - Berlin

Berlin, Wisconsin, 54923, United States
ThedaCare Cancer Care - New London

New London, Wisconsin, 54961, United States
ThedaCare Cancer Care - Oshkosh

Oshkosh, Wisconsin, 54904, United States
ThedaCare Cancer Care - Shawano

Shawano, Wisconsin, 54166, United States
ThedaCare Cancer Care - Waupaca

Waupaca, Wisconsin, 54981, United States
ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911, United States
ThedaCare Regional Medical Center - Appleton

Appleton, Wisconsin, 54911, United States
ThedaCare Regional Medical Center - Neenah

Neenah, Wisconsin, 54956, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
Tufts Medical Center Cancer Center Stoneham

Stoneham, Massachusetts, 02180, United States
UNC Pardee Cancer Center

Hendersonville, North Carolina, 28791, United States
UT Southwest

Dallas, Texas, 75235, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of Maryland Greenebaum Comprehensive Cancer Center

Baltimore, Maryland, 21201, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Wisconsin Carbone Cancer Center

Madison, Wisconsin, 53715, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Vanderbilt University

Nashville, Tennessee, 37232, United States
Vince Lombardi Cancer Clinic-Oshkosh

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States
Virtua Samson Cancer Center

Moorestown, New Jersey, 08057, United States
Virtua Voorhees

Voorhees Township, New Jersey, 08043, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.