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Can common drugs tame a racing heart when you stand?

NCT ID NCT00262470

Symptom relief Sponsor: Satish R. Raj Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests several medications to see if they can control the rapid heart rate and symptoms that occur when people with chronic orthostatic intolerance stand up. Researchers will give single doses of drugs like acetazolamide, atomoxetine, clonidine, entacapone, and propranolol to 150 participants. The goal is to find which drug works best to improve daily life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acetazolamide, Atomoxetine, Clonidine, Entacapone, Propranolol
What this could lead to
If successful, this could identify which medications best control heart rate and relieve symptoms for people with orthostatic intolerance.
What could go wrong
This is an early-phase trial with single doses, so results may not reflect long-term use. The drugs may cause side effects or not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 1997

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Chronic symptoms (\> 6 months) with standing upright Exclusion Criteria: * Obvious cause of hypovolemia or drugs that could worsen tachycardia * Chronic severe medical conditions such as cancer or ischemic heart disease

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Conditions

The condition(s) this trial relates to.

postural orthostatic tachycardia syndrome Tachycardia Tachycardia, Sinus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic orthostatic intolerance Tachycardia

Contacts and locations

Locations

  • Vanderbilt University Autonomic Dysfunction Center

    Nashville, Tennessee, 37232-2195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.