Organic vs. conventional: which crop grows a healthier gut?
NCT ID NCT07165145
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how eating organically or conventionally grown fruits and vegetables affects the bacteria in your gut and your overall health. Researchers will compare two groups: healthy adults and those with metabolic syndrome (a condition linked to obesity and high blood sugar). Participants will eat crops from one farming method, and scientists will track changes in blood sugar and gut bacteria. The goal is to see if farming practices can influence our health through the food we eat.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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44 people
The number who actually took part.
- Started
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Jun 2025
- Finished
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Nov 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 22 Healthy Volunteers : healthy Caucasian adults with a BMI \< 25 kg/m\^2 will be recruited with no medical conditions. * 22 Metabolically Impaired Participants: Caucasian adults with a BMI ranging from 28 kg/m\^2 to 40 kg/m\^2 with three components of Metabolic Syndrome, drug-naïve: * Elevated waist circumference (WC): with men having WC \> 102 cm (40 inches) and women having a WC \> 88 cm (35 inches). * High Fasting Plasma Glucose (FPG): a fasting plasma glucose level 110 mg/dL (6.1 mmol/L) * High Fasting Plasma Insulin (FPI): A fasting insulin level ≥25 μU/mL (or \>16.7 pmol/L) * HOMA-IR score of ≥2.5 Exclusion Criteria: * Use of antibiotic in the past 3 months or currently taking them * Past/ Currently following a vegan, strictly organic or vegetarian diet. * History of severe food allergies or intolerances that would render it unsafe for them to consume any of the fruits and vegetables provided. Exclusion will be determined on a case-by-case basis by the investigator. * Inability or unwillingness to collect stools. * Presence of overt type 1 diabetes mellitus (T1DM) and/or type 2 diabetes. * Use of medications for type 2 diabetes: metformin, statin, proton pump inhibitors (PPI), H2 blockers, pioglitazone, active GLP-1 receptor agonists (e.g., exenatide, liraglutide). * Prior or planned bariatric surgery, history of cholecystectomy. * History of cardiovascular disease, having a severe disease of the digestive tract, such as celiac disease, Crohn's disease, active ulcerative colitis. * Surgery scheduled for the trial duration period. * Pregnant or nursing women. * Smoking or illicit drug use. Use of \>5 units of alcohol daily on average. * History of neurological/neurodegenerative disorders. * Participation in another concomitant clinical trial. * Not residing in the Netherlands during study period (Sept-Nov 2025)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Amsterdam UMC, locatie AMC
Amsterdam, Amsterdam, 1105 AZ, Netherlands
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