Water vs. IV: could a simple drink prevent kidney damage from CT dye?
NCT ID NCT07459413
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares drinking water to receiving IV fluids for preventing kidney injury caused by contrast dye used in CT scans. Researchers will enroll 198 emergency department patients with mild-to-moderate kidney disease. Participants will either drink water or get IV fluids before and after their scan, and their kidney function will be checked 48-72 hours later.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Water (oral hydration)
- What this could lead to
- If successful, this could show that simply drinking water is as effective as IV fluids for protecting kidneys during CT scans, simplifying care.
- What could go wrong
- This is a small, early-stage trial (198 participants) and only tests a non-inferiority hypothesis. Results may not apply to all patients or settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 198 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged 18 years and older. * Patients with an estimated Glomerular Filtration Rate (eGFR) between 15-59 mL/min/1.73 m². * Patients undergoing contrast-enhanced computed tomography (CT) in the emergency department. * Patients who have provided written informed consent. Exclusion Criteria: * Pregnant women. * Patients with end-stage renal disease (ESRD) receiving dialysis or those with an eGFR \<15 mL/min/1.73 m². * Patients presenting with decompensated heart failure. * Patients with a known allergy to iodinated contrast media. * Patients with contrast media exposure within the last 72 hours. * Patients for whom oral intake is contraindicated or who cannot tolerate oral intake
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Gaziosmanpasa Training and Research Hospital
RECRUITINGIstanbul, Gaziosmanpasa, 34255, Turkey (Türkiye)
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