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Electric probe could spot mouth cancer without a biopsy

NCT ID NCT05430477

Diagnosis Sponsor: Ryan J. Halter Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a custom device that measures electrical impedance (how tissues resist electric current) in mouth lesions. Researchers enrolled 114 people with suspected oral cancer to see if the device could tell the difference between normal, benign, precancerous, and cancerous tissue. The goal was to create a database of measurements and images to improve future diagnosis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Electrical impedance imaging device (EII probe)
What this could lead to
If successful, this device could help doctors quickly identify which mouth lesions are cancerous without needing a biopsy.
What could go wrong
This is an early, completed study focused on data collection, not treatment. The device may not prove accurate enough for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

114 people

The number who actually took part.

Started

Aug 2022

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Potential study participants will be identified through Dartmouth-Hitchcock Medical Center (DHMC)'s Head and Neck Tumor Clinic, and will be patients with diagnosed or suspected cancer of the oral cavity, oropharynx, hypopharynx, or larynx who require biopsy or resection for either diagnostic or therapeutic purposes. This study will enroll 250 subjects in two cohorts. Cohort I will consist of 200 patients undergoing oral lesion biopsies. Cohort II will be comprised of 50 patients scheduled for oral cancer resection. A maximum of 5 additional subjects will be initially enrolled in each Cohort to optimize data acquisition.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Cohort 1 10.1.1 Inclusion Criteria 1. Suspected cancer the oral cavity, oropharynx, hypopharynx, or larynx requiring biopsy. 2. Ability to understand and the willingness to sign a written informed consent document. 3. Age ≥ 18 years old. 4. If a female of child bearing potential, then a negative pregnancy evaluation per standard of care. 10.1.2 Exclusion Criteria 1. Adults having had a previous oral biopsy within the last 30 days 2. Adults with implanted electrical devices such as pacemakers 3. Prisoners 4. Adults with impaired decision-making capacity 5. Has any condition for which, in the opinion of the investigator, contraindicates study participation. Cohort 2 10.2.2 Inclusion Criteria 1. Clinical diagnosis or suspected cancer the oral cavity, oropharynx, hypopharynx, or larynx requiring resection. 2. Ability to understand and the willingness to sign a written informed consent document. 3. Age ≥ 18 years old 4. If a female of child bearing potential, then a negative pregnancy evaluation per standard of care. 10.2.3 Exclusion Criteria 1. Adults with implanted electrical devices such as pacemakers 2. Prisoners 3. Adults with impaired decision-making capacity 4. Any condition for which, in the opinion of the investigator, contraindicates study participation.

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Conditions

The condition(s) this trial relates to.

benign neoplasm of oral cavity lip and oral cavity carcinoma oral mucosa leukoplakia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oral lesion

Contacts and locations

Locations

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire, 03756, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.