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New pill could tame tough eczema without creams

NCT ID NCT06775860

Disease control Sponsor: Beijing InnoCare Pharma Tech Co., Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This Phase 3 trial tests an oral drug called ICP-332 for people with moderate to severe atopic dermatitis (eczema) who haven't gotten enough relief from topical treatments. About 552 adults will receive either the drug or a placebo pill for several weeks. Researchers will measure how many achieve at least a 75% improvement in eczema severity and clear skin scores.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ICP-332 tablets
What this could lead to
If it works, this could provide a new oral treatment option for people with moderate to severe atopic dermatitis who haven't responded well to topical creams.
What could go wrong
This is still an experimental drug. Even in Phase 3, it may not prove more effective than placebo, and side effects are possible. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 552 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female subjects between 18 and 75 years of age. 2. Clinical diagnosis of chronic atopic dermatitis (also known as atopic eczema) for at least 1 year 3. Documented recent history of inadequate response to TCS or TCI, or for whom topical treatments are otherwise medically inadvisable. 4. Subjects must meet the following criteria for disease activity: * Eczema Area and Severity Index (EASI) score ≥ 16 ; * (Body Surface Area )BSA affected by AD ≥ 10% ; * (validated Investigator's Global Assessment-AD)vIGA-AD score ≥3 ; * Baseline weekly average of daily Worst Pruritus NRS ≥ 4. 5. Women of childbearing potential (WOCBP) and Men must agree 5\. Women of childbearing potential (WOCBP) and Men must agree to contraception. 6. Willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures. Exclusion Criteria: 1. Lack of response or inadequate response to prior treatment with any JAK inhibitor for AD. 2. Other active skin diseases or skin infections requiring systemic treatment or would interfere with appropriate assessment of atopic dermatitis lesions. 3. Pregnant or breastfeeding females. 4. History of any clinically major diseases, with the exception of atopic dermatitis. 5. Consideration by the Investigator, for any reason, that the subject is an unsuitable candidate to receive ICP-332 or participate in this study.

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Conditions

The condition(s) this trial relates to.

atopic eczema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atopic dermatitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    62 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Hospital of Chengde Medical University

    RECRUITING

    Chengde, Hebei, 067000, China

  • Affiliated Hospital of Hebei University of Engineering

    RECRUITING

    Handan, Hebei, 056002, China

  • Affiliated Hospital of Jiujiang University

    RECRUITING

    Jiujiang, Jiangxi, 332000, China

  • Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine

    RECRUITING

    Tianjin, Tianjin Municipality, 300120, China

  • Beijing Tongren Hospital, Capital Medical University

    RECRUITING

    Beijing, Beijing Municipality, 100730, China

  • Beijing Tsinghua Changgung Hospital

    RECRUITING

    Beijing, Beijing Municipality, 102218, China

  • Capital Medical University Affiliated Beijing Chaoyang Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100020, China

  • Capital Medical University Affiliated Beijing Friendship Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100050, China

  • Central South University Xiangya Hospital

    RECRUITING

    Changsha, Hunan, 410008, China

  • Changzhou First People's Hospital

    RECRUITING

    Changzhou, Jiangsu, 213003, China

  • Chengdu Second People's Hospital

    RECRUITING

    Chengdu, Sichuan, 610017, China

  • Chongqing Traditional Chinese Medicine Hospital

    RECRUITING

    Chongqing, Chongqing Municipality, 400021, China

  • Dermatology Hospital of Southern Medical University

    RECRUITING

    Guangzhou, Guangdong, 510091, China

  • General Hospital of Tianjin Medical University

    RECRUITING

    Tianjin, Tianjin Municipality, 300052, China

  • Hangzhou First People's Hospital

    RECRUITING

    Hangzhou, Zhejiang, 310006, China

  • Henan Provincial People's Hospital

    RECRUITING

    Zhengzhou, Henan, 450003, China

  • Jiangxi Provincial Dermatology Hospital

    RECRUITING

    Nanchang, Jiangxi, 330001, China

  • Jingzhou Central Hospital

    RECRUITING

    Jingzhou, Hubei, 434020, China

  • Jining First People's Hospital

    RECRUITING

    Jining, Shandong, 272011, China

  • Liuzhou People's Hospital

    RECRUITING

    Liuzhou, Guangxi, 545006, China

  • Nanfang Hospital, Southern Medical University

    RECRUITING

    Guangzhou, Guangdong, 510515, China

  • Peking University First Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100034, China

  • Peking University Third Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100191, China

  • Qilu Hospital of Shandong University

    RECRUITING

    Jinan, Shandong, 250012, China

  • Sanmenxia Central Hospital

    RECRUITING

    Sanmenxia, Henan, 472000, China

  • Second Affiliated Hospital of Hebei Medical University

    RECRUITING

    Shijiazhuang, Hebei, 050000, China

  • Shaanxi Provincial People's Hospital

    RECRUITING

    Xi'an, Shaanxi, 710068, China

  • Shandong Provincial Dermatosis Hospital

    RECRUITING

    Jinan, Shandong, 250022, China

  • Shanghai First People's Hospital

    RECRUITING

    Shanghai, Shanghai Municipality, 200080, China

  • Shanghai Skin Disease Hospital

    RECRUITING

    Shanghai, Shanghai Municipality, 200443, China

  • Shanghai Tenth People's Hospital

    RECRUITING

    Shanghai, Shanghai Municipality, 200072, China

  • Shenyang Hospital of Integrated Traditional Chinese and Western Medicine （Shenyang Seventh People's Hospital）

    RECRUITING

    Shenyang, Liaoning, 110001, China

  • Shenzhen Second People's Hospital

    RECRUITING

    Shenzhen, Guangdong, 518035, China

  • Sichuan Provincial People's Hospital

    RECRUITING

    Chengdu, Sichuan, 610072, China

  • Sir Run Run Hospital, Nanjing Medical University

    RECRUITING

    Nanjing, Jiangsu, 211166, China

  • The Affiliated Hospital of Inner Mongolia Medical University

    RECRUITING

    Hohhot, Inner Mongolia, 010050, China

  • The Affiliated Hospital of Qingdao University

    RECRUITING

    Qingdao, Shandong, 266003, China

  • The Affiliated Union Hospital of Fujian Medical University

    RECRUITING

    Fuzhou, Fujian, 350001, China

  • The First Affiliated Hospital of Anhui Medical University

    RECRUITING

    Hefei, Anhui, 230022, China

  • The First Affiliated Hospital of Chongqing Medical University

    RECRUITING

    Chongqing, Chongqing Municipality, 400016, China

  • The First Affiliated Hospital of Fujian Medical University

    RECRUITING

    Fuzhou, Fujian, 350005, China

  • The First Affiliated Hospital of Gannan Medical University

    RECRUITING

    Ganzhou, Jiangxi, 341000, China

  • The First Affiliated Hospital of Kunming Medical University

    RECRUITING

    Kunming, Yunnan, 650032, China

  • The First Affiliated Hospital of Nanchang University

    RECRUITING

    Nanchang, Jiangxi, 330006, China

  • The First Affiliated Hospital of Ningbo University

    RECRUITING

    Ningbo, Zhejiang, 315010, China

  • The First Affiliated Hospital of Wenzhou Medical University

    RECRUITING

    Wenzhou, Zhejiang, 325000, China

  • The First Affiliated Hospital of Xi'an Jiaotong University

    RECRUITING

    Xi'an, Shaanxi, 710061, China

  • The First Hospital of Jilin University

    RECRUITING

    Changchun, Jilin, 130021, China

  • The Fourth Affiliated Hospital, Zhejiang University School of Medicine

    RECRUITING

    Yiwu, Zhejiang, 322000, China

  • The Second Affiliated Hospital of Henan University of Science and Technology

    RECRUITING

    Luoyang, Henan, 471000, China

  • The Second Affiliated Hospital of Wannan Medical College

    RECRUITING

    Wuhu, Anhui, 241000, China

  • The Second Affiliated Hospital of Xiamen Medical College

    RECRUITING

    Xiamen, Fujian, 361021, China

  • The Second Affiliated Hospital, Zhejiang University School of Medicine

    RECRUITING

    Hangzhou, Zhejiang, 310009, China

  • The Second Xiangya Hospital of Central South University

    RECRUITING

    Changsha, Hunan, 410011, China

  • The Third People's Hospital of Hangzhou

    RECRUITING

    Hangzhou, Zhejiang, 310009, China

  • Wuhan Central Hospital

    RECRUITING

    Wuhan, Hubei, 430014, China

  • Wuhan Hospital of Traditional Chinese and Western Medicine (Wuhan No.1 Hospital)

    RECRUITING

    Wuhan, Hubei, 430022, China

  • Yancheng First People's Hospital

    RECRUITING

    Yancheng, Jiangsu, 224001, China

  • Yuebei People's Hospital

    RECRUITING

    Shaoguan, Guangdong, 512026, China

  • Yuncheng Central Hospital

    RECRUITING

    Yuncheng, Shanxi, 440000, China

  • Zhongshan University Sun Yat-sen Memorial Hospital

    RECRUITING

    Guangzhou, Guangdong, 510120, China

  • Zhongyi Northeast International Hospital Co., Ltd.

    RECRUITING

    Shenyang, Liaoning, 110179, China

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