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New mouth rinse could tame the fire of spicy foods instantly

NCT ID NCT07630571

Symptom relief Sponsor: Nakhia Impex LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 6 times

Summary

This pilot study tests whether a special hyaluronan oral solution can quickly ease the burning and irritation caused by spicy foods like chili peppers. Fifty healthy adults will have their mouths exposed to capsaicin (the spicy chemical) and then rinse with the test solution or a control. Pain and irritation are measured at several time points up to 90 seconds. The goal is to see if this rinse offers fast, non-drug relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
10% 35 kDa hyaluronan oral solution
What this could lead to
If it works, this could point toward a fast-acting, non-prescription rinse for soothing mouth pain or irritation from spicy foods or mild oral discomfort.
What could go wrong
This is a very early, small pilot study with only 50 healthy people. The pain is artificially induced, so results may not apply to real-world oral pain conditions. Also, it's open-label, which can bias results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Jun 2026

Finished

Jul 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-65 years, healthy adults * Able to tolerate capsaicin/AITC oral challenge * Able to complete NRS assessments * Signed informed consent Exclusion Criteria: * Oral ulcers, lesions, or mucosal disease * Known hyaluronan allergy * Severe systemic disease * Pregnancy/lactation * Recent oral analgesic use (≤24h)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aitc-induced irritation Capsaicin-induced pain Oral mucosa discomfort Oral pain Oral pungent sensation

Contacts and locations

Locations

  • HA35

    Qingdao, Shandong, 266000, China

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