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Toothbrush vs. sponge: which oral care method best fights pneumonia in ICU patients?

NCT ID NCT07283380

Disease control Sponsor: Marmara University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using a pediatric toothbrush or a sponge stick for mouth care can reduce harmful bacteria and prevent ventilator-associated pneumonia (VAP) in ICU patients on breathing machines. Seventy-two adults will be randomly assigned to one of the two methods for five days. Researchers will measure bacteria levels and use a pneumonia scoring system to see which approach works better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
0.12% chlorhexidine (included in both oral care sets)
What this could lead to
If one method proves better, it could lead to a simple, low-cost change in ICU oral care routines to reduce pneumonia risk.
What could go wrong
This is a small, early-stage study (72 patients) comparing two common methods, so results may not be definitive or widely applicable. The study only looks at short-term effects over 5 days.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who have been on invasive mechanical ventilation for less than 24 hours. * Patients who provide informed consent through their legal representative or themselves if capable. * Patients with no prior oral surgery, no head or neck trauma, and no contraindications to oral care. * Patients aged 18 years or older. Exclusion Criteria: * Patients under 18 years of age. * Patients who have been on mechanical ventilation for more than 24 hours before enrollment. * Patients with oral surgical procedures or trauma to the head or neck. * Patients with contraindications to oral care, such as severe oral bleeding, mucositis, or active oral infections. * Patients or legal representatives who do not provide informed consent.

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Conditions

The condition(s) this trial relates to.

Pneumonia, Ventilator-Associated

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ventilator-associated pneumonia (VAP)

Contacts and locations

Locations

  • Zonguldak Ataturk State Hospital

    Zonguldak, 67000, Turkey (Türkiye)

  • Zonguldak Atatürk State Hospital, Ministry of Health, Türkiye

    Zonguldak, 67000, Turkey (Türkiye)

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