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Can food vouchers and peer support keep women on HIV prevention pills?

NCT ID NCT06274060

Prevention Sponsor: Johns Hopkins Bloomberg School of Public Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed trial in South Africa tested four support strategies—case management, food vouchers, peer buddies, and community PrEP pick-up points—to help female sex workers and young women stay on PrEP, a daily pill that prevents HIV. 304 participants were randomly assigned to different combinations of these strategies. The goal was to see which approaches best encourage long-term PrEP use, so these services can be expanded to other districts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
case management, food vouchers, peer support buddies, community-based PrEP pick-up points
What this could lead to
If successful, this could identify the best support strategies to help women at high risk for HIV consistently take PrEP, potentially reducing new HIV infections in South Africa.
What could go wrong
This is a completed phase 2b trial with 304 participants, so results may not apply to all women or regions. The strategies may not work as well outside the study setting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

304 people

The number who actually took part.

Started

Apr 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Initiated PrEP within the past 48 hours by the TB HIV Care PrEP programme in uMgungundlovu through the female sex worker (FSW) or adolescent girls and young women (AGYW) PrEP programme teams Exclusion Criteria: * Not eligible for PrEP * Currently on PrEP, but initiated onto PrEP more than 48 hours previously * Under 16 years of age if AGYW OR under 18 years of age if FSW

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV infections Pre-exposure prophylaxis

Contacts and locations

Locations

  • TB HIV Care

    Pietermaritzburg, KwaZulu-Natal, 3200, South Africa

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Other studies related to the condition(s) this trial covers.