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Timing is everything: brain zaps paired with robot training may boost stroke recovery

NCT ID NCT06612437

Symptom relief Sponsor: The Hong Kong Polytechnic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether the time gap between two types of brain stimulation affects arm and hand recovery in people with chronic stroke. 62 participants received either a short or long interval between inhibitory and excitatory stimulation, followed by robot-assisted arm training. The goal was to find the best timing to improve movement and coordination.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If successful, this could help identify the best way to use brain stimulation to boost motor recovery after stroke, potentially improving rehabilitation outcomes.
What could go wrong
This is a small, early-stage study focused on timing parameters, not a treatment itself. Results may not apply to all stroke patients or lead to a clear clinical benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

62 people

The number who actually took part.

Started

Oct 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. diagnosis of hemorrhagic or ischemic stroke using computed tomography (CT) or magnetic resonance imaging (MRI). 2. the first-ever stroke with unilateral hemiplegia. 3. 18-75 years old. 4. chronic stroke ( ≥ 6 months). 5. residual hemiparetic upper limb functional level in the Functional Test for the Hemiplegic Upper Extremity (FTHUE-HK) ≥ 2. 6. can understand and read Chinese. 7. signed informed consent. Exclusion Criteria: 1. diagnosis of any clinically significant or unstable medical disorder. 2. any contraindications to TMS based on the TMS safety guidelines (Rossi, Hallett, Rossini, \& Pascual-Leone, 2011). 3. inability to follow treatment instructions due to severe cognitive (using the Hong Kong version of the Montreal Cognitive Assessment (MoCA-HK) \< 22/30) and communication deficiency. 4. extreme spasticity over the hemiparetic upper limb (Modified Ashworth Score\>2) or severe pain that hindered movement. 5. a history of neurological or psychiatric disease excluding stroke, or current use of psychoactive medication (sedatives, antipsychotics, antidepressants, etc.).

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke Stroke rehabilitation

Contacts and locations

Locations

  • The Hong Kong Polytechnic University

    Hong Kong, HK, Hong Kong

  • The Hong Kong Polytechnic University

    Hong Kong, Hong Kong

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