Eye-Opening study: which anesthesia reversal drug is safer for your eyes?

NCT ID NCT07666984

Knowledge-focused Sponsor: Cukurova University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two drugs—sugammadex and neostigmine—used to reverse muscle relaxation after surgery. Researchers will measure the optic nerve sheath diameter (the nerve behind the eye) using ultrasound at key times during recovery. The goal is to see if one drug causes less swelling or pressure on the eye nerve. The trial involves 86 healthy adults undergoing planned surgery, randomly assigned to receive one of the two drugs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Sugammadex and Neostigmine (with Atropine)
What this could lead to: If successful, this study could help anesthesiologists choose the safer drug to reverse muscle relaxation, potentially reducing eye pressure risks during recovery.
What could go wrong: This is a small, early-phase study focused on a temporary measurement (optic nerve sheath diameter) rather than long-term outcomes. Results may not apply to all patients or surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 86 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * With an ASA physical status of 1-2 * Patients scheduled for elective surgery * Patients willing to participate in the study Exclusion Criteria: * Patients with heart, liver, kidney, or respiratory failure * Brain tumors, hemorrhages, or aneurysms * Patients who have undergone eye, cardiovascular, or neurosurgery * Eye or neurological diseases or increased intracranial pressure * Laparoscopic surgeries * Cases not in the supine position * Allergy to the medications used * Patients who did not provide informed consent to participate in the study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neuromuscular blockade reversal agent

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Eye-Opening study: which anesthesia reversal drug is safer for your eyes?

What the study statuses mean