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Spinal block may speed up chemo start after cancer surgery

NCT ID NCT07153614

Symptom relief Sponsor: University of Tennessee Graduate School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether using spinal morphine or other nerve blocks instead of standard opioid painkillers can help patients start chemotherapy sooner after cancer surgery. 200 adults having open surgery for stomach, liver, pancreas, or colorectal cancer will be randomly assigned to one of three pain-block methods. The main goal is to see if the spinal morphine group begins chemo earlier than the others.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intrathecal morphine, bupivacaine, dexamethasone, and Exparel-based solution
What this could lead to
If it works, this could show that using spinal morphine before surgery helps patients start chemotherapy sooner after cancer surgery.
What could go wrong
This is a small, early-stage study (200 people) comparing different pain-block methods. Results may not apply to all surgeries or patients, and pain blocks carry rare risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 18-80 years of age 2. Patients undergoing open surgery for foregut, HPB, and colorectal cancer 3. Able to read and understand study procedures 4. Willing to participate and sign an ICF 5. If female of childbearing potential, subject must have a negative pregnancy test 6. Recommended for adjuvant chemotherapy 7. Patients scheduled for an AM admit procedure 8. English speaking 9. Patients with a midline incision Exclusion Criteria: 1. Chronic Opioid Use (received an opioid within 90 days preoperatively) 2. Recreational Drug Use 3. Patients with cognitive impairments that can affect their ability to give consent 4. Patients that are currently taking anti-coagulants \<7 days prior to surgery 5. Pregnant or breastfeeding 6. Does not require adjuvant chemotherapy 7. Relative Contradictions for receiving a nerve block\* 8. Patients that have been admitted prior to surgery for chief complaint related to complications from malignancy 9. Inability to provide consent * Absolute Contraindications * Lack of patient consent. * Skin infection at the site of needle insertion. Relative Contraindications * Coagulopathy * Systemic infection * Anatomical distortion * Neuropathy Drugs/Device usage within 7 Days of Randomization if any: • Anticoagulants

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Perioperative opioid sparing techniques

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Tennessee Graduate School of Medicine

    RECRUITING

    Knoxville, Tennessee, 37920, United States

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