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Can skipping opioids during surgery speed up recovery?

NCT ID NCT07665463

Symptom relief Sponsor: Jagiellonian University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 2 times

Summary

This study tests whether avoiding opioid painkillers during major urologic surgery leads to better recovery. About 200 adults will be randomly assigned to receive either opioid-free anesthesia (using other drugs) or standard opioid-based anesthesia. The main goal is to see how patients feel one week after surgery, using a recovery questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Opioid-free anesthesia (dexmedetomidine, ketamine, lidocaine) vs remifentanil-based anesthesia
What this could lead to
If it works, this could show that avoiding opioids during surgery improves recovery and reduces side effects like nausea.
What could go wrong
This is a small, early-stage trial (200 patients) and may not prove long-term benefits. The opioid-free approach might not control pain as well.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 75 years. * Scheduled for elective major urological surgery under general anesthesia, including laparoscopic or robotic nephrectomy, laparoscopic or robotic prostatectomy, or laparoscopic or robotic cystectomy. * Ability to operate a patient-controlled analgesia pump postoperatively. * Ability to understand and use the Numeric Rating Scale for pain assessment. * Ability to understand and complete the Quality of Recovery-15 questionnaire. * Written informed consent. Exclusion Criteria: * Patient refusal to participate. * Inability to operate the patient-controlled analgesia pump. * Inability to understand the Numeric Rating Scale for pain assessment. * Inability to understand or complete the Quality of Recovery-15 questionnaire. * Known hypersensitivity to any of the study drugs, including anesthetics, ketamine, dexmedetomidine, lidocaine, ropivacaine, oxycodone, metamizole, paracetamol, or ibuprofen. * Second- or third-degree atrioventricular block. * Symptomatic bradycardia. * Chronic opioid use. * Contraindication to the planned regional anesthesia technique, including coagulopathy, therapeutic anticoagulation, or infection at the puncture site.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesics, opioid Anesthesia, general Postoperative recovery Urologic surgical procedure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Intensive Interdisciplinary Care, Collegium Medicum, Jagiellonian University

    RECRUITING

    Krakow, Lesser Poland Voivodeship, 30-688, Poland

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