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Can skipping opioids during surgery improve recovery?

NCT ID NCT07739641

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial asks whether avoiding opioids during general anesthesia can improve recovery quality in women undergoing laparoscopic hysterectomy. It compares an opioid-free approach using dexmedetomidine and ketamine with a standard fentanyl-based anesthesia. The study tracks postoperative pain, nausea and vomiting, and the need for rescue pain medication. Participants are women aged 40-65 scheduled for elective laparoscopic hysterectomy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Opioid-free anesthesia using dexmedetomidine and ketamine, compared to fentanyl-based anesthesia
What this could lead to
If opioid-free anesthesia works well, it could offer a way to reduce postoperative nausea and vomiting while managing pain effectively, improving recovery after hysterectomy.
What could go wrong
This is a small trial, and results may not apply to all patients. Opioid-free anesthesia might not control pain as well as opioids, and the drugs used have their own side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 66 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Undergoing a scheduled laparoscopic hysterectomy surgery under general anaesthesia. * Age group: 40-65 years old. * BMI\<35. * ASA I-II. Exclusion Criteria: * Emergency hysterectomy. * Allergy to any of the drugs used in the study. * HR \< 50 bpm (chronic treatment by beta blockers, heart block patients). * Alcohol or drug abuse. * Psychiatric disease. * Liver impairment. Kidney impairment

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Conditions

The condition(s) this trial relates to.

Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post operative analgesia Post operative nausea and vomiting (PONV) Post operative recovery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ain Shams

    Cairo, Abbasia, 00202, Egypt

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