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Heart surgery without morphine: a safer way?

NCT ID NCT03816592

Symptom relief Sponsor: Centre Hospitalier Universitaire Dijon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether using a combination of lidocaine, ketamine, and dexamethasone instead of opioids during heart surgery could lower the need for morphine afterward and reduce complications. 110 adults having heart surgery with a heart-lung machine took part. The goal was to see if this opioid-free approach improves recovery and well-being.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine, ketamine, and dexamethasone
What this could lead to
If it works, this could offer a way to reduce morphine use and side effects after heart surgery.
What could go wrong
This is a small, single-center study. The approach may not work for everyone, and there is always a risk of inadequate pain control without opioids.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

110 people

The number who actually took part.

Started

Jan 2019

Finished

Mar 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Cardiac surgical

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age over 18 years * cardiac surgery with cardiopulmonary bypass Exclusion Criteria: * patient with chronic analgesia treatment * patient on antidepressive therapy * gabapentin use * preoperative cognitive dysfunction * patient treated with zyvoxid

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Opioid anaesthesia Opioid free anaesthesia

Contacts and locations

Locations

  • Chu Dijon Bourogne

    Dijon, 21000, France

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