Can a nerve block replace opioids after gallbladder surgery?
NCT ID NCT07750769
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial tests whether combining an opioid-free anesthesia protocol with a specific nerve block can control pain after laparoscopic gallbladder removal. Half of the participants will receive the nerve block plus opioid-free anesthesia, while the other half will receive only the opioid-free protocol. The study measures how much extra opioid painkiller is needed in the first six hours after surgery, aiming to see if the nerve block reduces opioid consumption.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Opioid-free anesthesia protocol combined with an ultrasound-guided external oblique intercostal plane (EOI) nerve block
- What this could lead to
- If successful, this approach could reduce opioid use after gallbladder surgery, lowering the risk of opioid-related side effects and dependence.
- What could go wrong
- This is a small, early-stage trial, and the nerve block may not provide enough pain relief for all patients. There are also risks of bleeding, infection, or local anesthetic allergy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients scheduled for elective laparoscopic cholecystectomy (LC) surgery under general anesthesia, American Society of Anesthesiologists (ASA) physical status I-II, aged from 18 to 65 years old of either sex Exclusion Criteria: * Contraindications to regional block (coagulopathy, infection at the needle insertion site, or known allergy to amide local anesthetics) * Pregnancy or breastfeeding women * Body mass index (BMI) \> 35 Kg/m2 * History of hepatic, renal, or cardiac disease * Chronic opioid use, or history of chronic pain (pain present for more than 6 months) * Thoracic deformity * Neuropsychiatric disorders * Patient refusal.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.