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Opioid-Free anesthesia may keep blood pressure steady during brain surgery

NCT ID NCT06791811

Symptom relief Sponsor: Kasr El Aini Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared opioid-free anesthesia (using dexmedetomidine and lidocaine) to standard opioid anesthesia in 86 adults having brain tumor surgery. The goal was to see if the opioid-free approach better controlled blood pressure during stressful moments like drilling into the skull. Researchers measured how many patients had a big blood pressure spike during the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

86 people

The number who actually took part.

Started

Mar 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. ASA Ι and II. 2. Patients undergoing resection of supratentorial tumors in supine position. 3. Age (18-50) years. 4. Both sexes. Exclusion Criteria: 1. Impaired renal functions. 2. Uncontrolled systemic hypertension(patients with sustained elevated blood pressure more than 140/90). 3. Cardiac arrhythmias (any rhythm other than normal sinus rhythm and sinus tachycardia). 4. Heart failure(impaired cardiac contractility ,EF less than 45%.). 5. Patients receiving more than 2 units of blood during surgery. 6. Patients with large masses and expected severe increase in ICP. 7. Patients requiring vasopressors infusion. 8. The need for postoperative ventilation at the end of study. 9. Glasgow coma scale less than 14. 10. History of allergy to the study drugs. 11. Surgeries lasting more than 4 hours. 12. Pregnancy. 13. Bronchial asthma.

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Conditions

The condition(s) this trial relates to.

supratentorial cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Supra-tentorial tumor

Contacts and locations

Locations

  • Cairo University

    Cairo, Cairo Governorate, 11742, Egypt