Can a simple pill ease gagging during a throat scope? new study explores ondansetron for EGD comfort.
NCT ID NCT07264738
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tests whether taking ondansetron, a common anti-nausea drug, before an unsedated throat scope (EGD) can reduce gagging, nausea, and overall discomfort. About 40 Chinese patients who have had this exam before will either receive ondansetron plus a numbing gargle, or just the gargle. After the procedure, they will rate their discomfort and gagging to see if the drug helps.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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40 people
The number who actually took part.
- Started
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Jul 2025
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * patients scheduled for follow-up EGD at PUMCH * Signing a written informed consent. Exclusion Criteria: * Contraindications for esophagogastroduodenoscopy. * History of upper gastrointestinal tract surgery. * With conditions indicated for emergency EGD, such as upper gastrointestinal bleeding * Severe diseases of the heart, kidney, respiratory system, central nervous system, and hematopoietic system. * Pregnancy. * Neuropsychiatric disorders, severe depression and severe anxiety. * Allergy to ondansetron or dyclonine hydrochloride.
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, 100730, China
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