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Common nausea drug may stabilize blood pressure in elderly surgery patients

NCT ID NCT07551219

Symptom relief Sponsor: Ankara City Hospital Bilkent Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether ondansetron, a drug often used for nausea, can reduce dangerous drops in blood pressure and heart rate in older adults (65+) undergoing spinal anesthesia for urologic surgery. Researchers tracked 140 patients to see if those who received ondansetron had fewer episodes of low blood pressure or slow heart rate during surgery. The goal was to find a simple way to make anesthesia safer for elderly patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

140 people

The number who actually took part.

Started

Dec 2024

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of geriatric patients aged 65 years and older undergoing elective urologic surgery under spinal anesthesia. Patients were managed according to routine clinical practice, with or without prophylactic ondansetron administration. Perioperative hemodynamic parameters, including blood pressure and heart rate, were prospectively recorded during the intraoperative period.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 65 years and older Patients scheduled for elective urologic surgery under spinal anesthesia American Society of Anesthesiologists (ASA) physical status I-III Patients who received routine perioperative management, with or without ondansetron administration Patients who provided written informed consent Exclusion Criteria: * Refusal or contraindication to spinal anesthesia Known hypersensitivity or contraindication to ondansetron Preexisting severe cardiac conduction abnormalities (e.g., high-grade atrioventricular block, sick sinus syndrome) Baseline bradycardia (heart rate \< 50 beats per minute) Chronic use of medications significantly affecting heart rate or blood pressure (e.g., beta-blockers, calcium channel blockers, antiarrhythmic drugs) Emergency surgery Incomplete perioperative hemodynamic data

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Conditions

The condition(s) this trial relates to.

Bradycardia hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bradycardia Hypotension Hypotension during surgery Spinal anesthesia induced hemodynamic change

Contacts and locations

Locations

  • Ankara Bilkent City Hospital

    Ankara, Ankara, Turkey (Türkiye)

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