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Tiny study aims to unlock why Weight-Loss surgery works differently for everyone

NCT ID NCT02757638

Knowledge-focused Sponsor: Texas A&M University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at how the body digests and uses food during weight loss from bariatric surgery. Researchers used advanced 'omics' techniques to track nutrients in 7 participants. The goal was to understand why weight loss varies between people and to generate ideas for more personalized treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
stable isotope infusion (glycerol, D2O, tyrosine, phenylalanine, glucose, arginine, citrulline)
What this could lead to
If successful, this could help doctors personalize weight-loss treatments based on individual metabolism.
What could go wrong
This is a very small, early-stage study (only 7 participants) that aims to generate hypotheses, not prove a treatment works. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

7 people

The number who actually took part.

Started

Feb 2016

Finished

Jun 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria obese subjects: * Diagnosed with morbid obesity (defined as BMI \> 40 kg/m2 or BMI \> 35 kg/m2 with at least one serious comorbidity (1991 NIH compendium guidelines)) * Scheduled for bariatric surgery * Age 18 years and older * Ability to lie in supine or elevated position for 9 hours * Willingness and ability to comply with the protocol Inclusion criteria healthy subjects: * Healthy male or female according to the investigator's or appointed staff's judgment * Ability to walk, sit down and stand up independently * Age 18 years or older * Ability to lie in supine or elevated position for 9 hours * Willingness and ability to comply with the protocol Exclusion Criteria * Any condition that may interfere with the definition 'healthy subject' according to the investigator's judgment (for healthy control group only) * Presence of fever within the last 3 days * Untreated metabolic diseases including hepatic or renal disorder unrelated to the primary disease * Presence of acute illness or metabolically unstable chronic illness unrelated to the primary disease * (Possible) pregnancy * Any other condition according to the PI or nurse that would interfere with the study or safety of the patient * Failure to give informed consent * Use of protein or amino acid containing nutritional supplements within 3 days of first test day

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Conditions

The condition(s) this trial relates to.

morbid obesity Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Surgery

Contacts and locations

Locations

  • Texas A&M University-CTRAL

    College Station, Texas, 77843, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.