New opioid aims to ease pain without slowing digestion
NCT ID NCT07307495
First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times
Summary
This study tests whether a new painkiller called oliceridine fumarate can control pain after lumbar spine surgery while helping the gut recover faster. Standard opioids often cause constipation and slow digestion. The trial will compare oliceridine to the usual drug sufentanil in 428 adults undergoing back surgery. Researchers will measure how quickly patients can eat solid food and pass gas or have a bowel movement within 24 to 48 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- oliceridine fumarate
- What this could lead to
- If it works, this could offer a painkiller option that causes less constipation and helps the gut recover faster after surgery.
- What could go wrong
- This is an early-stage trial with no phase assigned, so results are uncertain. The drug may not prove better than existing options, and side effects are still being studied.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 428 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 18 and 75 years old; * Patients undergoing lumbar surgery under general anesthesia (within 3 segments) and expected to receive postoperative patient-controlled analgesia; * ASA classification I-III; * BMI between 18 and 30 kg/m²; * Informed consent obtained from the patient. Exclusion Criteria: * Use of any painkillers within 3 days before surgery; or long-term treatment with non-steroidal anti-inflammatory drugs (NSAIDs), defined as: within 3 months before surgery, use of NSAIDs daily for more than 2 consecutive weeks; * Presence of intestinal obstruction or suspicious symptoms: nausea and vomiting, abdominal bloating and pain, cessation of gas or bowel movements within the past two weeks, imaging suggesting intestinal dilation, or large amounts of air-fluid levels; * Patients with severe liver dysfunction (based on Child-Pugh classification, grade C); * History of or planned gastrointestinal surgery; * Patients allergic to the study drug; * Pregnant or breastfeeding patients; * QTcF abnormalities, males \>450 ms, females \>470 ms; * Participation in other drug trials within the past 30 days; * Long-term use of opioids (defined as: within 12 months before surgery, use for more than 1 month, more than 3 days per week, with daily doses exceeding 15 mg morphine equivalent); * Pre-existing neurological or psychiatric disorders: such as epilepsy, depression, schizophrenia, etc.; * Patients deemed unsuitable for this study by the investigator.
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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the First Affiliated Hospital of Air Force Military Medical University
RECRUITINGXi'an, Shaanxi, 710043, China