New eye drop takes on vuity in Pupil-Size showdown
NCT ID NCT06783686
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-phase study tested whether a new eye drop called NV701 works better than the existing drop Vuity for shrinking pupil size in people with presbyopia (age-related blurry near vision). Fifty-five adults aged 40-55 received one dose of each drop in different eyes. Researchers measured pupil size over 8 hours to see which drop caused more constriction.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Pilocarpine 1.25% eye drops
- What this could lead to
- If NV701 works better than Vuity, it could offer a more effective option for temporarily improving near vision in people with presbyopia.
- What could go wrong
- This is a very early, small study (55 people) testing only a single dose. It may not show a meaningful difference, and results may not apply to long-term use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
-
55 people
The number who actually took part.
- Started
-
Jan 2025
- Finished
-
May 2025
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
40 to 55 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 40-55 years with presbyopia * Able to understand and willing to sign the informed consent for the study * Resting mesopic pupil diameter of \>4 mm in both eyes * Change in mesopic pupil diameter of \>1 mm after 1 hour in response to pilocarpine 1.25% in both eyes * Willing to abstain from contact lens use for 7 days before the study visit * Women of childbearing age must have a negative urine pregnancy test at the screening visit and be willing to use a reliable method of birth control during the study Exclusion Criteria: * Anisocoria \>1 mm in photopic or mesopic conditions * High myopia (-6.00 diopters or greater) * Any iris abnormality making it difficult to judge pupil diameter as determined by the principal investigator * Known allergy to any of the study products or medications * Concurrent use of any topical prescription ophthalmic products * History of uveitis or intraocular inflammation * Inability to complete any of the study procedures * History of ocular surgery other than LASIK or PRK * History of retinal tear or retinal detachment * Presence of retinal lattice degeneration, operculated hole, or other retinal pathology on screening exam. * History of punctal plugs or punctal cautery in one or both eyes * History of nasolacrimal duct surgery in one or both eyes * History of blepharoplasty or ptosis surgery in one or both eyes * History of glaucoma, glaucoma suspect or ocular hypertension diagnosis * History of acute angle closure or laser peripheral iridotomy * History of moderate or severe dry eye disease * Females who are pregnant, nursing, or planning a pregnancy during the study * Females of childbearing potential and males with partners of childbearing potential who do not agree to use reliable contraception during the study * Uncontrolled systemic disease
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Arizona Eye Center
Chandler, Arizona, 85224, United States
-
Global Research Management, Inc
Glendale, California, 91204, United States
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