Can a better diet during malnutrition recovery rewire a Child's brain?
NCT ID NCT05629624
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This study looks at whether specially designed nutritional supplements can improve thinking skills and emotional control in young children in Bangladesh who have moderate malnutrition. About 300 children aged 1 to 3 years receive either standard or enhanced nutritional supplements along with a psychosocial stimulation program. Researchers measure changes in brain activity and development using tests and brain imaging.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- special nutritional supplements (E-RUSF and E-SQLNS) plus psychosocial stimulation
- What this could lead to
- If successful, this could show that targeted nutrition during early childhood recovery from malnutrition can improve brain development and emotional regulation.
- What could go wrong
- This is a small pilot study, so results may not apply broadly. The supplements may not outperform standard feeds, and long-term benefits remain uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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297 people
The number who actually took part.
- Started
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Feb 2022
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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12 to 39 months
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion criteria: Inclusion criteria for malnourished (MAM) children at 1 and 3 years of age: All of the following criteria must be met for a subject to be eligible to participate in the study * Mother willing to sign consent form * Child age 12-15 months or 36-39 months of age * WHZ \<-2 and ≥-3 z-score, and/or MUAC \<12.5 and ≥11.5 cm and free from any acute illness * Mother agrees to feed their children a study diet at home. * Mother willing to bring the child to the clinic for assessment (morbidity, nutrition history, adherence to treatment, anthropometry and advice to mother on parenting) and clinical examination. * Mother will agree to provide her biological samples * Mother willing to have a child undergo biological sample collection and neuropsychological assessment at baseline (1-year-old) and at ages 2 years and 3 years at the clinic. * Family has no plan to move from the study area in the next three years. Inclusion criteria for Control group with normal health (normal Z score): * Mother willing to sign consent form * Child age 12-15 months * WHZ score \> -1 and free from any acute illness * Mother willing to bring the child to the clinic for assessment (morbidity, nutrition history, adherence to treatment, anthropometry and advice to mother on parenting) and clinical examination. * Mother will agree to provide her biological samples (see below). * Mother willing to have a child undergo biological sample collection and neuropsychological assessment at baseline at 1 year old and again at 2 years and 3 years at the clinic. * Family has no plan to move from the study area in the next two years. Exclusion Criteria: Exclusion criteria for malnourished (MAM) children: Meeting any of the following criteria will exclude a subject from study participation * Mother who is not willing to sign a consent form. * Congenital anomaly. * Mother who is not willing to feed the rehabilitation feed or the small quantity supplement to her child. * Family will not stay 3 years in the study area. Exclusion criteria for Control group with normal health (normal Z score): Meeting any of the following criteria will exclude a subject from study participation - * Mother who is not willing to sign a consent form. * Child age \>15 months or \< 12m. * Mother who is not willing to feed the rehabilitation feed or the small quantity supplement to her child. * Family will not stay 3 years in the study area. * Any congenital anomaly.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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International Centre for Diarrheal Disease Research
Dhaka, Bangladesh
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Other studies related to the condition(s) this trial covers.
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