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Nerve block showdown: which numbing drug keeps blood pressure steadier during brain surgery?

NCT ID NCT07188987

Disease control Sponsor: Kasr El Aini Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two numbing medicines, prilocaine and lidocaine, given as a nerve block behind the nose during pituitary tumor surgery. The goal is to see which one better controls blood pressure swings and reduces the need for extra painkillers. About 54 adults aged 21-45 having this surgery will take part.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
prilocaine or lidocaine (numbing medicines)
What this could lead to
If one works better, it could give surgeons a simple way to keep blood pressure steady during pituitary surgery, reducing bleeding and improving the view.
What could go wrong
This is a small, early study with only 54 people. The nerve block may not control blood pressure well, and both drugs carry rare risks like allergic reactions or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Feb 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with pituitary adenoma undergoing endoscopic hypophysectomy. * ASA physical status I and II. * Age above 21, below 45 years. * Male or female Exclusion Criteria: * Any patient below 21 years or above 45 years. * Patients suffering from any of the following conditions: * Disturbed conscious level. * Coagulation abnormalities. * Poorly controlled blood pressure and/or heart rate. * Increased intracranial tension. * Liver and kidney disorders. * Patients on anticoagulants and/or NSAIDS (non-steroidal anti- inflammatory drugs * Patients addicted to drugs and/or alcohol. * Patients with disturbed conscious level at the end of the surgery, GCS \>14

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Conditions

The condition(s) this trial relates to.

pituitary gland adenoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood pressure control

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kasr El Ainy

    RECRUITING

    Cairo, 11956, Egypt

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