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Can a vitamin B3 pill help older veterans stay stronger longer?

NCT ID NCT04691986

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study tests whether nicotinamide riboside (NR), a form of vitamin B3, can improve muscle strength, endurance, and walking speed in older veterans aged 65-85. Participants take NR or a placebo daily for several weeks and undergo exercise tests and muscle biopsies. The goal is to see if boosting NAD+ levels can slow age-related muscle decline and frailty.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nicotinamide riboside (a form of vitamin B3)
What this could lead to
If it works, this could point toward a simple nutritional supplement to help older adults maintain muscle strength and mobility.
What could go wrong
This is a small, early-stage trial with 74 participants, so results may not apply broadly. The supplement may not improve physical function beyond a placebo effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

74 people

The number who actually took part.

Started

Sep 2023

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ages 65-85 * Male or female * Any race * Ability to use an exercise bike * Medically cleared for muscle biopsy Exclusion Criteria: * Severe Co-morbidity * examples include, but not limited to: * congestive heart failure class equal to or above III * chronic obstructive pulmonary disorder (COPD) gold stage IV * chronic kidney disease equal to or above stage * A VA-SLUMS cognitive screen score of less than or equal to 20 * Body mass index greater than or equal to 40

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Conditions

The condition(s) this trial relates to.

Frailty Inflammation Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Muscle quality and nad+ content Nicotinamide adenine dinucleotide concentration Sarcopenia

Contacts and locations

Locations

  • Kansas City VA Medical Center, Kansas City, MO

    Kansas City, Missouri, 64128-2226, United States

More trials for these conditions

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