Which drug keeps moms and babies safer during C-Sections?

NCT ID NCT06248593

Disease control Sponsor: Hassan II University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study compares two drugs, norepinephrine and phenylephrine, given as continuous infusions to maintain blood pressure during planned C-sections under spinal anesthesia. 140 healthy pregnant women will receive one of the two drugs, and researchers will measure effects on the baby's umbilical cord blood and the mother's vital signs. The goal is to find which drug offers better safety and stability for both mother and child.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: norepinephrine and phenylephrine (drugs to raise blood pressure)
What this could lead to: If one drug proves safer or more effective, it could become the preferred choice for managing blood pressure during C-sections, improving outcomes for mothers and newborns.
What could go wrong: This is a small, single-center trial comparing two well-known drugs, so the results may not apply to all hospitals or patients. Neither drug is expected to be a breakthrough.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Full-term, singleton, pregnant women, nonlaboring. * Scheduled for elective cesarean delivery under spinal anesthesia, * American Society of Anesthesiologists physical status : 1 or 2 * Baseline systolic BP between 90 and 140 mm Hg. Exclusion Criteria: * Known fetal abnormality. * Preexisting or pregnancy-induced hypertension, cardiovascular, cerebrovascular or kidney disease. * Contraindication to spinal anesthesia. * Peripartum hemorrhage. * Body mass index above 40 kg/m2.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cesarean section complications Hypotension

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Which drug keeps moms and babies safer during C-Sections?

What the study statuses mean