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Which drug works best for blood pressure drops during emergency surgery?

NCT ID NCT07259655

Disease control Sponsor: Hopital Charles Nicolle Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two drugs, norepinephrine and ephedrine, for treating low blood pressure that can happen after anesthesia in emergency abdominal surgery. About 100 adults were randomly assigned to receive one of the drugs when their blood pressure dropped. The goal was to see which drug restores blood pressure faster and with fewer doses.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
norepinephrine and ephedrine
What this could lead to
If this trial succeeds, it could show that norepinephrine is more effective than ephedrine for quickly stabilizing blood pressure during emergency abdominal surgery.
What could go wrong
This trial was terminated, so results may be incomplete. It is a small, single-center study, and findings may not apply to all patients or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

100 people

The number who actually took part.

Started

Mar 2025

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years. * Digestive emergencies: Appendicitis, cholecystitis, peritonitis, penetrating wounds, strangulated hernia or eventration, intestinal obstruction, complicated diverticulitis, mesenteric ischemia, gastrointestinal perforation. * Patients classified according to the American Society of Anesthesiologists (ASA) classification as I, II, and stable III Exclusion Criteria: * Non-consenting patients. * Presence of a rhythm disorder. * Patients with pulmonary hypertension . * heart failure. * intra-abdominal hypertension. * Presence of active bleeding. * patients using vasopressors at the start of the procedure. * pregnant women. * Septic or hemorrhagic shock requiring catecholamines.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-induction hypotension

Contacts and locations

Locations

  • Hospital of Charles Nicolle

    Tunis, Tunis Governorate, 1006, Tunisia

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