Blood test could replace needle for down syndrome screening
NCT ID NCT02127515
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 31 times
Summary
This study tested whether a noninvasive blood test (NIPT) is as good as the standard invasive test for detecting Down syndrome in over 2,000 pregnant women at higher risk. Women were randomly assigned to receive either the blood test or the usual invasive procedure. The goal was to see if NIPT could reduce miscarriages and the need for invasive tests while still being accurate.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Hôpital Necker- Enfants Malades
Paris, 75015, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Non Invasive Prenatal Testing (blood test)
What this could lead to
If successful, NIPT could replace invasive tests like amniocentesis, reducing the risk of miscarriage while still detecting Down syndrome accurately.
What could go wrong
This is a completed trial, but NIPT is a screening test, not a diagnosis—false positives or negatives can still occur. It may not be suitable for all pregnancies.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.