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New MRI scan could spare kidney transplant patients painful biopsies

NCT ID NCT07333495

Diagnosis Sponsor: Tongji Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether advanced, non-contrast MRI scans can safely and accurately monitor the health of transplanted kidneys. Currently, doctors rely on blood tests and invasive biopsies, which can miss early signs of trouble. Researchers will scan 1000 participants, including both kidney donors and recipients, to see if MRI can detect problems like rejection earlier and more precisely. If it works, this could lead to a gentler, more personalized way to care for transplant patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
non-contrast functional magnetic resonance imaging (MRI)
What this could lead to
If successful, this could replace invasive biopsies with a simple MRI scan to catch kidney transplant problems early, improving long-term outcomes.
What could go wrong
This is an early exploratory study, so the MRI method may not prove accurate enough to replace current tests. Results may vary across different hospitals and patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2033

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study will enroll adult (age ≥18 years) kidney transplant recipients and their corresponding donors from multiple participating transplant centers. This hybrid cohort comprises two distinct sub-populations: Paired Donor-Recipient Cohort: Includes both the transplant recipient and the living or deceased donor from whom the kidney originated. Independent Recipient Cohort: Includes transplant recipients (primarily from deceased donors) for whom paired donor baseline data is not available. All enrolled participants will undergo a standardized, non-contrast functional MRI assessment.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Adult participants (age ≥ 18 years). For the Paired Donor-Recipient Cohort: Donor: Scheduled for living kidney donation, OR is a deceased organ donor who can undergo a pre-transplant MRI. Recipient: Recipient of a kidney transplant or simultaneous pancreas-kidney transplant from the paired donor. For the Independent Recipient Cohort: Recipient: Recipient of a kidney transplant from a deceased donor for whom donor baseline data is unavailable. Able to provide informed consent. Exclusion Criteria: Any contraindication to MRI (e.g., cardiac pacemaker, non-MRI compatible metallic implants, neurostimulators, severe claustrophobia). Inability to tolerate the breath-holding required for MRI acquisition. Pregnancy. Any clinical condition that, in the investigator's judgment, would severely compromise study participation or data integrity (e.g., uncontrolled severe infection, active major psychiatric illness).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney transplant Renal allograft Renal allograft recipients

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Shanxi Medical University

    NOT_YET_RECRUITING

    Taiyuan, Shanxi, China

  • Sinopharm Dongfeng General Hospital, Dongfeng Motor Corporation and Hubei University of Medicine.

    NOT_YET_RECRUITING

    Shiyan, Hubei, China

  • Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

    RECRUITING

    Wuhan, Hubei, China

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