Dissolvable threads go Head-to-Head in the quest for a nonsurgical facelift
NCT ID NCT06454994
First seen Sep 11, 2026 · Last updated Sep 11, 2026
Summary
Researchers are testing whether a brand of dissolvable PDO lifting threads, Noble Lift, works as well as an existing brand, Croquis, for lifting the eyebrows, mid-face, and jawline. In this split-face study, 65 adults receive one brand on one side of the face and the other brand on the other side, so each person acts as their own comparison. Doctors rate how much the face improves using a 5-point scale, and they track jowl laxity, patient satisfaction, and photographs for 12 months. The study also monitors safety and side effects of the threads and the procedure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Noble Lift PDO lifting threads, a resorbable suture device used for nonsurgical face lifting
- What this could lead to
- If the threads perform as well as the comparator, they could offer another nonsurgical option for people seeking a temporary lift of the eyebrows, mid-face, or jawline.
- What could go wrong
- This is a small, 65-person study of a cosmetic device, so results may not reflect how the threads perform in a wider range of skin types and faces. Thread lifts can cause bruising, swelling, dimpling, or asymmetry, and the lifting effect fades as the threads dissolve.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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65 people
The number who actually took part.
- Started
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Jun 2024
- Finished
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Feb 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * BMI comprised between 18.5 and 30 * No ongoing or planned diet. * Group 1: requiring an aesthetic treatment of upper face with resorbable threads. * Group 2: Subject requiring an aesthetic treatment of mid-face and lower-face with resorbable threads * Subject with dense and not too thin skin. Exclusion Criteria: * Pregnant or nursing woman or planning a pregnancy during the study; * Suffering from a severe or progressive disease or any other pathology that may interfere with the evaluation of the study result and/or subject safety, especially cardiac disorder, non-controlled high blood pressure, diabetes, panic disorders, depression, active auto-immune disease, cold, high fever,… * Suffering from malnutrition. * Acute inflammatory process or infection, or history of chronic or recurrent infection or inflammation with the potential to interfere with the study results or increase the risk of adverse events. * Wound healing disorder or with a disorder that may impact wound healing such as connective tissue or immunosuppressive disorder. * History of precancerous lesions/skin malignancies. * Active skin disease within 6 months of study entry. * Scars, rosacea, herpes, acne, blotches or other pathology in the face, at the investigator appreciation. * Predisposed to keloidosis or hypertrophic scarring. * Known history of hyper- or hypo-pigmentation in the face. * Known history of multiple allergies, allergic/anaphylactic reactions including allergy/ hypersensitivity to lidocaine, anaesthetics of the amide type, the used antiseptic components, the used antibiotic cream components. * Known bleeding disorder or is receiving medication that will likely increase the risk of bleeding during treatment. * Extensive skin laxity, thin skin and/or severe malar fat sagging. * Foreign body sensitivity or known or suspected allergies to implant or instrument materials in particular plastic/biomaterial. * Any medication which may interfere, at the interpretation of the investigator, with the study objectives in term of efficacy and safety/tolerance. * Dental care in the past 2 weeks or who planned to receive dental care in the 2 months after the treatment. * Anticoagulant (such as aspirin, warfarin, blood circulation enhancer and clotbuster) during the week before the injection session . * Chemotherapy agents, immunosuppressive medications or systemic corticosteroids in the past 3 months and during the study. * Lifting of the face in the past 12 months or other surgery of the face in the past 6 months. * Resorbable fillers within the past 12 months, other resorbable threads within the past 12 months, neurotoxin in the past 5 months or plans to receive such treatments during the study. * Permanent filler on the face. * Subcutaneous permanent retaining structure on the face (meshing, permanent threads, gold strand etc.). * Intensive exposure to sunlight or UV-rays within the previous month and/or foreseen during the study.
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dr Converset-Viethel
Lyon, France
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Dr Facchinetti
Cannes, France
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Dr Jeanblanc
Aix-en-Provence, France
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Dr Lemmel
Paris, France
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