MRI reveals whether popular wrinkle fillers migrate after injection

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. At the time of consent, male or female participants 18 years of age and older; 2. Participants with established facial volume loss and/or contour deficits; 3. Accepted the obligation not to receive any other facial procedures throughout the study duration; 4. Understood and accepted the obligation and would be logistically able to appear for all scheduled follow-up visits; 5. No previous facial fillers for 18 months prior to this study; 6. Capable of providing informed consent, approved by an independent ethics committee, prior to the initiation of any screening or study-specific procedures; 7. Participants must be willing and able to comply with procedures required in the protocol. 8. Participants must be in good health as per investigator's judgment based on medical. history. 9. Female participants of childbearing potential must be willing practice at least 1 protocol-specified method of birth control that is effective from Baseline through at least 30 days after the last dose or until the end of study, whichever is longer. Female participants of non-childbearing potential do not need to use birth control Exclusion Criteria: 1. Current Pregnancy or lactation \[sexually active women of childbearing age must agree to use medically acceptable methods of contraception for the duration of this study (e.g., oral contraceptives, condoms, intrauterine device, shot/injection, patch)\]; 2. Hypersensitivity to Restylane products, HA filler or amide local anesthetics; 3. Participants presenting with porphyria or any other liver diseases; 4. Inability to comply with follow-up and abstain from facial injections during the study period; 5. Heavy smokers, classified as smoking more than 12 cigarettes per day; 6. History of severe or multiple allergies manifested by anaphylaxis, since drug allergies might preclude optimal management of complications; 7. Previous tissue revitalization therapy in the treatment area within 6 months before treatment with laser or light, mesotherapy, radiofrequency, ultrasound, cryotherapy, chemical peeling, or dermabrasion; 8. Previous facial surgery, including liposuction; 9. Lifetime history of permanent implants in the treatment region; 10. History in the last 18 months of semi-permanent dermal fillers (e.g., poly-L-lactic acid, polyalkylimide, polymethylmethacrylate, polytetrafluoroethylene, and silicone), synthetic implantation and/or autologous fat transplantation in the treatment region; 11. History or presence of any disease or lesion near or at the treatment area, including inflammation, active or chronic infection, including in the mouth, dentals, head and neck region; 12. Participant has an uncontrolled systemic diseases 13. Participants present with or have a history of any medical condition that may place the participant at increased risk following exposure to hyaluronic acid or interfere with the study evaluation, including: * Diagnosed myasthenia gravis, Lambert-Eaton syndrome, amyotrophic lateral sclerosis, or any other significant disease that might interfere with neuromuscular function * History of facial nerve palsy * Infection or dermatological condition at the treatment injection sites * Marked facial dermatochalasis, deep dermal scarring, excessively thick sebaceous skin, or excessively photodamaged skin 14. Facial psoriasis, eczema, acne, rosacea, perioral dermatitis, herpes zoster or any other facial condition that may increase the risk of cutaneous penetration of infective agents; 15. Scars, deformities, piercing, or tattoos in the treatment areas; 16. Facial cancer or precancer (e.g., actinic keratosis); 17. History of radiation therapy to the treatment area; 18. History of bleeding disorders, or treatment with thrombolytics, anticoagulants, or inhibitors of platelet aggregation (e.g., Aspirin or other non-steroid anti-inflammatory drugs \[NSAIDs\]), within 2 weeks before treatment; 19. Participants with active immune disorders such as systemic lupus erythematosus, rheumatoid arthritis, mixed connective tissue disease, and Hashimoto's thyroiditis, or participants using immunosuppressants; 20. Participants with a tendency to form hypertrophic or keloid scars, or any other healing disorders; 21. Participants with known hypersensitivity to lidocaine or agents structurally related to amide type local anaesthetics (e.g., certain anti-arrhythmics); 22. Participants administered dental block or topical administration of lidocaine within 2 weeks of treatment; 23. Participants with epilepsy, impaired cardiac conduction, severely impaired hepatic function or severe renal dysfunction; 24. Current remote infections (e.g., urinary tract, sinuses, intestinal tract, oral cavity); 25. Planned dental procedures during the 2-week period before and after filler treatments, including teeth cleaning, tooth extraction and gum grafts. 26. Planned COVID-19 vaccinations during the 2-week period before and after filler treatments. 27. History of cystic acne (for those that will be treated in the chin region). 28. Female participants that is pregnant or breastfeeding and is considering becoming pregnant or donating eggs during the study or for approximately 30 days after the last dose of study medical device or until the end of study, whichever is longer 29. Anticipated need for surgery or hospitalization during the course of the study 30. History of other treatment/procedure that, in the treating investigator's opinion, would interfere with the study injections and/or study assessments or exposes the participant to undue risk by study participation. 31. Contraindications for Magnetic Resonance Imaging (MRI) such as: * Implanted pacemakers or defibrillators * Metallic implants of any kind including cochlear implants and orthodontics * Claustrophobia * Pregnancy * Loud noises